In the PI3K/AKT/mTOR pathway, CCL5/CCR5 phosphoryl
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Posted On: 11/30/2024 3:12:31 AM
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In the PI3K/AKT/mTOR pathway, CCL5/CCR5 phosphorylates 4E-BP1, which pushes mTOR-4E-BP1/S6K1-eIF4F pathway forwards. As soon as mTOR, a tyrosine kinase, receiving signaling from CCL5/CCR5-PI3K/AKT, it phosphorylates 4E-BP1, S6K1 and eIF4F gradually. After that, activated eIF4F disassociates 5′-untranslated region (UTR) and promotes mRNA translation.
https://www.sciencedirect.com/science/article...422100101X
There's the pathway I proposed that leronlimab would disrupt thus acting as an antiviral in Covid. The other of course is the balancing of CD4/CD8 ratios.
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