Would Leronlimab protect microglia clusters in the

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Would Leronlimab protect microglia clusters in the brains of people with Alzheimer's?

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Three of the clusters hadn't been seen before, and one of them was more common in people with Alzheimer's disease. This type of microglia has genes turned on that are involved in inflammation and cell death.

Overall, the researchers found that microglia clusters in the brains of people with Alzheimer's disease were more likely to be those in a pre-inflammatory state.

This means they were more likely to produce inflammatory molecules that can damage brain cells and possibly contribute to the progression of Alzheimer's disease.

The microglia types in the brains of people with Alzheimer's disease were less likely to be protective, compromising their ability to pull their weight in cleaning up dead cells and waste and promoting healthy brain aging.
https://www.msn.com/en-us/health/other/brain-...&ei=13

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Microglia are brain and central nervous system macrophages. Just like what leronlimab does in the rest of the body there would be an M2 (anti-inflammatory) to M1 (inflammatory) macrophage/microglia shift. But the CCR5 blockade would mute the overactive inflammatory response so you'd still have the M1 microglia cleaning up dead cells and waste without the damaging effects of inflammation or the blocking of that cleanup by excessive M2 microglia. It's all about balance.

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"At this point, we can't say whether the microglia are causing the pathology or whether the pathology is causing these microglia to alter their behavior," said Prater.

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There must be an underlying inflammatory cause even if low level. Possibly a combination of genetics or genetics combined with environmental factors. The bump up in cytokines would cause the microglia to go into overdrive. Which in turn would increase the amount of cytokines in a vicious little circle.