Inhibition of CCR5 increased MAPK/CREB signaling

Inhibition of CCR5 increased MAPK/CREB signaling and enhanced memory, whereas CCR5 overexpression resulted in memory impairment and decreased plasticity (31). It was also reported that CCL5 and CCR5 overexpression during aging was associated with memory impairment in mice, which was reversed by knocking out the CCR5 gene through gene editing or pharmacologic inhibition with maraviroc (32). However, activation of CCR5 by CCL3 impaired synaptic plasticity of hippocampal neurons and memory, which can be alleviated by application of the CCR5 inhibitor maraviroc (33). Thus, the above evidence indicates that CCL5/CCR5 axis plays an important role in neurocognitive function, which also provides potential clues for exploring the pathogenesis of disorders associated with cognitive deficits.

https://academic.oup.com/jnen/article/82/11/8...ogin=false