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Streaming new MANF Research x3
(1) MANF in Sjögren's syndrome
MANF inhibits Sjögren's syndrome salivary gland epithelial cell apoptosis and antigen expression of Ro52/SSA through endoplasmic reticulum stress/autophagy pathway
Journal of International Immunopharmacology
Authors: Anhui Medical University, China
https://pubmed.ncbi.nlm.nih.gov/37393840/
Result: It was found that MANF could reduce lymphocyte infiltration and the proportion of CD4+ T cell subsets in the salivary glands, reduce the phosphorylation of AKT and mTOR proteins and the expression of ERS-related proteins, and increase the expression of autophagy proteins. We also found that MANF can reduce the expression of Ro52/SSA antigen on the cell membrane and reduce apoptosis.
Conclusion: In short, we found that MANF can activate autophagy, inhibit apoptosis and reduce the expression of Ro52/SSA by regulating the AKT/mTOR/LC3B signaling pathway. The above results suggest that MANF may be a protective factor against SS.
(2) A great overview of CNFK and MANF research
CDNF and MANF in the brain dopamine system and their potential as treatment for Parkinson’s disease
Frontiers in Psychiatry
Authors: University of Helsinki, Finland
https://www.frontiersin.org/articles/10.3389/...88697/full
In conclusion, CDNF and MANF are neuroprotective proteins that can modulate UPR signaling and inhibit inflammatory processes, both of which are potentially relevant to PD pathogenesis. Since ER stress and inflammation are interconnected processes, deeper understanding of their complex interplay and the potential roles of CDNF and MANF in these processes, could benefit development of new therapeutic strategies for PD.
(3) MANF in Periodontitis
Effect of mesencephalic astrocyte-derived neurotrophic factor on the inflammatory response in human gingival fibroblasts cells
European Journal of Oral Science
Authors: Hospital of Qingdao University
https://pubmed.ncbi.nlm.nih.gov/37461146/
We found that MANF could inhibit pro-inflammatory cytokine secretion, alleviate the endoplasmic reticulum stress response, promote cell survival, and inhibit cell apoptosis. Therefore, MANF might be a novel promising target for the treatment of periodontitis.
(1) MANF in Sjögren's syndrome
MANF inhibits Sjögren's syndrome salivary gland epithelial cell apoptosis and antigen expression of Ro52/SSA through endoplasmic reticulum stress/autophagy pathway
Journal of International Immunopharmacology
Authors: Anhui Medical University, China
https://pubmed.ncbi.nlm.nih.gov/37393840/
Result: It was found that MANF could reduce lymphocyte infiltration and the proportion of CD4+ T cell subsets in the salivary glands, reduce the phosphorylation of AKT and mTOR proteins and the expression of ERS-related proteins, and increase the expression of autophagy proteins. We also found that MANF can reduce the expression of Ro52/SSA antigen on the cell membrane and reduce apoptosis.
Conclusion: In short, we found that MANF can activate autophagy, inhibit apoptosis and reduce the expression of Ro52/SSA by regulating the AKT/mTOR/LC3B signaling pathway. The above results suggest that MANF may be a protective factor against SS.
(2) A great overview of CNFK and MANF research
CDNF and MANF in the brain dopamine system and their potential as treatment for Parkinson’s disease
Frontiers in Psychiatry
Authors: University of Helsinki, Finland
https://www.frontiersin.org/articles/10.3389/...88697/full
In conclusion, CDNF and MANF are neuroprotective proteins that can modulate UPR signaling and inhibit inflammatory processes, both of which are potentially relevant to PD pathogenesis. Since ER stress and inflammation are interconnected processes, deeper understanding of their complex interplay and the potential roles of CDNF and MANF in these processes, could benefit development of new therapeutic strategies for PD.
(3) MANF in Periodontitis
Effect of mesencephalic astrocyte-derived neurotrophic factor on the inflammatory response in human gingival fibroblasts cells
European Journal of Oral Science
Authors: Hospital of Qingdao University
https://pubmed.ncbi.nlm.nih.gov/37461146/
We found that MANF could inhibit pro-inflammatory cytokine secretion, alleviate the endoplasmic reticulum stress response, promote cell survival, and inhibit cell apoptosis. Therefore, MANF might be a novel promising target for the treatment of periodontitis.
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