Prognostic potential of serum mesencephalic astroc
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Posted On: 06/03/2023 6:39:28 AM
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Prognostic potential of serum mesencephalic astrocyte-derived neurotrophic factor in acute intracerebral hemorrhage: a prospective observational study
The Quzhou Affiliated Hospital of Wenzhou Medical University
Zhang, CL., Fang, LL., Wang, CL. et al. Prognostic potential of serum mesencephalic astrocyte-derived neurotrophic factor in acute intracerebral hemorrhage: a prospective observational study. BMC Neurol 23, 213 (2023). https://doi.org/10.1186/s12883-023-03254-y
Conclusions
Since MANF is in possession of neuroprotective effects, this clinical epidemiological investigation was implemented to determine whether serum MANF levels are altered after human ICH. It is found that serum MANF levels are significantly increased, have independent correlation with admission NIHSS scores, baseline hematoma volumes and post-stroke 90-day mRS scores, are associated with END and poor 90-day prognosis independently, show efficient prognostic predictive potential and exhibit additive effect of prognostic ability when combined with NIHSS scores and hematoma scores. Conceivably, such data are strongly supportive of the notion that serum MANF may be accurately reflective of stroke severity and neurological outcome of human ICH, as well as its determination may be of clinical significance.
https://bmcneurol.biomedcentral.com/articles/...23-03254-y
The Quzhou Affiliated Hospital of Wenzhou Medical University
Zhang, CL., Fang, LL., Wang, CL. et al. Prognostic potential of serum mesencephalic astrocyte-derived neurotrophic factor in acute intracerebral hemorrhage: a prospective observational study. BMC Neurol 23, 213 (2023). https://doi.org/10.1186/s12883-023-03254-y
Conclusions
Since MANF is in possession of neuroprotective effects, this clinical epidemiological investigation was implemented to determine whether serum MANF levels are altered after human ICH. It is found that serum MANF levels are significantly increased, have independent correlation with admission NIHSS scores, baseline hematoma volumes and post-stroke 90-day mRS scores, are associated with END and poor 90-day prognosis independently, show efficient prognostic predictive potential and exhibit additive effect of prognostic ability when combined with NIHSS scores and hematoma scores. Conceivably, such data are strongly supportive of the notion that serum MANF may be accurately reflective of stroke severity and neurological outcome of human ICH, as well as its determination may be of clinical significance.
https://bmcneurol.biomedcentral.com/articles/...23-03254-y
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