Leronlimab would potentially play a key role for sepsis due to the fulminant inflammatory response associated with it but there are a cast of characters in what can otherwise be a fatal event if there is no full court press as far as supporting measures and treatment: stat antibiotics (eg: vancomycin, zosyn, meropenem…) are crucial while finding the underlying cause (chest x-Ray, rule out pneumonia, blood cultures etc), vasopressors (norepinephrine, dobutamine), steroids for septic shock along with fluid bolus (normal saline is typical).