Ohm, is Ehlers-Danlos Syndrome on your indication

Ohm, is Ehlers-Danlos Syndrome on your indication list or research list? I just caught an Article about it. Inherited to be sure, but collagen ‘Deformities’ and multi-system ‘appearance of symptoms’ often lead to a life-time of misdiagnoses. Not a ton of research and not finding CCR5 yet. But collagen, multi-system, and immuno- deficiency to be sure. Also known as an hyper-flexibility disorder that leads to broken bones, joint and spinal injuries. Considered rare, but probably greatly under diagnosed.

“She explains that undiagnosed patients might consult a neurologist for their migraines, a rheumatologist for joint pain, a cardiologist for palpitations, a gastroenterologist for digestive issues and a urologist for bladder symptoms. Each doctor focuses on the symptoms that fall within their specialty but doesn't consider the other ailments. "Nowhere along the way does somebody realize that there are certain conditions that could tie all of these things together and explain everything," says Bluestein.”

https://www.cnn.com/2022/12/24/health/hypermo...index.html

“Classical Ehlers-Danlos syndrome (EDS) is characterized by skin hyperelasticity, joint hypermobility, increased tendency to bruise, and abnormal scarring. Mutations in type V collagen, a regulator of type I collagen fibrillogenesis, have been shown to underlie this type of EDS.”

https://pubmed.ncbi.nlm.nih.gov/10739762/

“People with Ehlers-Danlos Syndrome (EDSers) may have higher risk for infections. Fragile skin and poor healing may lead to skin infections. EDSers often have a lowered immune system, possibly due to chronic stress on multiple body systems or an IgG-3 deficiency.”

https://www.chronicpainpartners.com/ehlers-da...nfections/

“Mast Cell Activation Syndrome and Mechanosensitivity of Mast Cells Within Hypermobile Type Ehlers-Danlos Syndromes
Mast cell activation disorder (MCAD) is a family of immunological disorders in which mast cells degranulate, i.e., release their granules containing histamine and other substances, unusually easily (Hamilton, 2018). Mast cells are derived from multipotential hematopoietic stem cells (MHSCs) which then differentiate into mast cell progenitors (MCPs). These MCPs then leave the circulatory system and migrate into connective and mucosal tissue where they proliferate and differentiate into mast cells (Kitamura et al., 2007). Mast cells are filled with granules filled histamine, heparin, and various cytokines among other pro inflammatory molecules. When triggered, mast cells degranulate, i.e., release the contents of their granules into the surrounding tissues (Krystel-Whittemore et al., 2016).”

https://www.frontiersin.org/articles/10.3389/...74840/full

Anyhoo Fun to think about. The collagen connection got me thinking.