Pfizer's danuglipron is an agonist that upregulates GLP-1. Once again a drug that targets only one small piece of the puzzle. Leronlimab upregulates GLP-1 along with the myriad of other effects. Interestingly another GLP-1 agonist called Rybelsus has been approved by the FDA to treat type 2 diabetes. Rybelsus has a black box warning for a host of very bad side effects.