Ohm,
I’m honestly not surprised that pro-inflammatory
Ohm,
I’m honestly not surprised that pro-inflammatory cytokines were upregulated in response to higher doses of Leronlimab.
“What really caught my eye is the astonishingly large difference in Pro-Inflammatories between 350mg and 700mg. The level of blockade would correspond to a more pronounced drop in level of those chemokines”
The multiple and overlapping feedback loops are what maintains homeostasis across multiple biological systems. With CCR5 blockade, the resultant cytokine increase is a response to maintain the signaling, albeit pathologic, which Leronlimab interrupts. An attenuated response to previous cytokine levels may result in increased cyokkne release and upregulation of CCR5 (or parallel/similarly functioning receptors such as CCR2.
I don’t believe anything is as simple with our immune system as one would hope, especially with CCR5 which seems simultaneously more variable and pervasive than other GPCRs.
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