When CCR5 is internalized, it is no longer express

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When CCR5 is internalized, it is no longer expressed on the surface of the cell, but when it is bound to LL, it remains expressed. Could this mean that when LL is fully dosed, it actually enters the cell, finds the internalized CCR5, dislodges the bound ligand, binds to CCR5 and then the combined CCR5+LL is expressed on the cell surface? That would increase their numbers.

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Leronlimab is not an agonist, it only binds to CCR5, never enters the cell and remains inert. The increased numbers are only because the leronlmab bound CCR5 never internalizes as it would ordinarily do when bound by chemokines.