What would be great is free floating leronlimab in
Post# of 154675
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Posted On: 05/28/2022 1:05:16 PM
What would be great is free floating leronlimab in the CNS fluid where it can access every brain cell.
Its my understanding that many brain cells which do not face the blood still express CCR5. So if unbound leronlimab can get into the CNS fluid, it could bind to these cells.
If indeed leronlimab's entrance into the brain is by piggy-back on CD4 cells, and if indeed leronlimab binding to CCR5 is so tight that leronlimab never dissociates from CCR5, then the only brain cells leronlimab can hit are white blood cells.
Which may be just exactly what is needed for many diseases. But still not as good as hitting all CCR5 receptors in the brain.
Getting into the CNS in humans is not really that hard. Many medicines are administered intrthecally (spinal tap). I think Cytodyn could easily test this out in other mammals, monkeys for sjure.
Its my understanding that many brain cells which do not face the blood still express CCR5. So if unbound leronlimab can get into the CNS fluid, it could bind to these cells.
If indeed leronlimab's entrance into the brain is by piggy-back on CD4 cells, and if indeed leronlimab binding to CCR5 is so tight that leronlimab never dissociates from CCR5, then the only brain cells leronlimab can hit are white blood cells.
Which may be just exactly what is needed for many diseases. But still not as good as hitting all CCR5 receptors in the brain.
Getting into the CNS in humans is not really that hard. Many medicines are administered intrthecally (spinal tap). I think Cytodyn could easily test this out in other mammals, monkeys for sjure.
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