You go down the rabbit hole and sometimes run into

You go down the rabbit hole and sometimes run into something completely different. Looking for something else I ran into the GPR75 receptor. It seems to have no direct connection to CCR5. But it does bind CCL5 (RANTES). With more free CCL5 available due to CCR5 blockade by leronlimab that should increase the binding activity of CCL5 to GPR75. CCL5 does not activate GPR75 but the competitive binding blockis 20-HETE binding resulting in downregulation of CA2+ (calcium), b-arrestin (implicated in increased cell entry of the Covid-19 virus), IP-1 (inositol monophosphate) (implicated in bi-polar disorder and possibly other psychiatric disorders) and Nf-kb.