Nice find. This coincidence is hard to believe, b
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Posted On: 12/09/2021 11:15:41 PM
Re: chazzledazzle #112146
Nice find. This coincidence is hard to believe, but my neuromuscular neurology colleague and I are this week working on a neurodiagnostic testing protocol for stiff person's syndrome, as we just saw such a patient two weeks ago. Many SPS patients have anti-GAD or autoimmunity against GABA receptor associated proteins.
I was telling him about CAR-TRegs and destroying specific population of auto antigen producing B cells only, but other immunomodulatory drugs could help too. Will take a look at the tocilizumab and Covid paper. I wonder if it was Covid and not tocilizumab that led to regression of SPS symptoms?
I'm still trying to wrap my head around how LL can work to suppress autoimmunity in say GVHD and perhaps something like SPS, yet also increase natural immunity in cancer.
I was telling him about CAR-TRegs and destroying specific population of auto antigen producing B cells only, but other immunomodulatory drugs could help too. Will take a look at the tocilizumab and Covid paper. I wonder if it was Covid and not tocilizumab that led to regression of SPS symptoms?
I'm still trying to wrap my head around how LL can work to suppress autoimmunity in say GVHD and perhaps something like SPS, yet also increase natural immunity in cancer.
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