Bear with me on this one, Stiff Persons Disease.
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Posted On: 12/09/2021 10:53:34 PM
Bear with me on this one, Stiff Persons Disease.
After re-posting those autism papers, I took a look at what Autoantibodies are. There's a list of them and the associated diseases on wikipedia. Interestingly enough, the list includes both celiacs disease and coeliacs disease.
It also includes Stiff Persons Disease - the rare neurologic disorder involving progressive stiffness of the truncal muscles accentuated by spasms resulting in deformities, chronic pain, deformities, and even broken bones. That sounded immediately like a possible nervous system issue, so I wanted to check it out for cytokines and inflammation etc.
It's origins are misunderstood, but sometimes follows diabetes as well as, breast, ovarian, small cell lung and renal cancers.
While poking around the interwebs, I found this article about a 51 year old women whose Stiff Persons Syndrome was sorta cured after a bout with severe/critical covid. She was intubated with ARDS and needed treatment Tocilizumab. The article suggests the MAB was the reason her stiffness syndrome subsided.
https://n.neurology.org/content/96/15_Supplement/2397
"In April 2020, she was admitted for COVID-19 infection complicated by acute respiratory distress syndrome (ARDS), which necessitated intubation, sedation and mechanical ventilation. During her hospitalization she received hydroxychloroquine, azithromycin, convalescent plasma and tocilizumab (400mg/2 doses at an interval of 2 weeks). After being weaned off sedation, she observed that stiffness of right lower extremity had significantly improved, and she no longer had any tonic spasms. She was able to walk without support and continued to do so at 3-month follow up. Her glucose control has also improved significantly requiring less insulin."
"Conclusions: We hypothesize that tocilizumab is the likely cause of significant improvement in our patient’s condition. Anti-GAD antibodies are known to elicit T-Helper 2 response, which increases production of cytokines such as Interleukin (IL-4) and IL-6. Tocilizumab, an IL-6 inhibitor, has shown significant clinical improvement in patients with other autoimmune encephalitis who were refractory to rituximab in case-control studies. This has never been studied in SPS. We suggest that it may be a feasible option to consider for patients with SPS, who are refractory to traditional treatments including weekly IVIG"
I'm not suggesting a new indication to possibly add to the list, but this reminds me of the cool, unexpected stuff that will be seen in patients that are given Leronlimab someday.
Imagine get LL for HIV, and then your diabetes, COPD, and arthrosclerosis gets better. Dang, that's gonna be fun to see.
chazzle
After re-posting those autism papers, I took a look at what Autoantibodies are. There's a list of them and the associated diseases on wikipedia. Interestingly enough, the list includes both celiacs disease and coeliacs disease.
It also includes Stiff Persons Disease - the rare neurologic disorder involving progressive stiffness of the truncal muscles accentuated by spasms resulting in deformities, chronic pain, deformities, and even broken bones. That sounded immediately like a possible nervous system issue, so I wanted to check it out for cytokines and inflammation etc.
It's origins are misunderstood, but sometimes follows diabetes as well as, breast, ovarian, small cell lung and renal cancers.
While poking around the interwebs, I found this article about a 51 year old women whose Stiff Persons Syndrome was sorta cured after a bout with severe/critical covid. She was intubated with ARDS and needed treatment Tocilizumab. The article suggests the MAB was the reason her stiffness syndrome subsided.
https://n.neurology.org/content/96/15_Supplement/2397
"In April 2020, she was admitted for COVID-19 infection complicated by acute respiratory distress syndrome (ARDS), which necessitated intubation, sedation and mechanical ventilation. During her hospitalization she received hydroxychloroquine, azithromycin, convalescent plasma and tocilizumab (400mg/2 doses at an interval of 2 weeks). After being weaned off sedation, she observed that stiffness of right lower extremity had significantly improved, and she no longer had any tonic spasms. She was able to walk without support and continued to do so at 3-month follow up. Her glucose control has also improved significantly requiring less insulin."
"Conclusions: We hypothesize that tocilizumab is the likely cause of significant improvement in our patient’s condition. Anti-GAD antibodies are known to elicit T-Helper 2 response, which increases production of cytokines such as Interleukin (IL-4) and IL-6. Tocilizumab, an IL-6 inhibitor, has shown significant clinical improvement in patients with other autoimmune encephalitis who were refractory to rituximab in case-control studies. This has never been studied in SPS. We suggest that it may be a feasible option to consider for patients with SPS, who are refractory to traditional treatments including weekly IVIG"
I'm not suggesting a new indication to possibly add to the list, but this reminds me of the cool, unexpected stuff that will be seen in patients that are given Leronlimab someday.
Imagine get LL for HIV, and then your diabetes, COPD, and arthrosclerosis gets better. Dang, that's gonna be fun to see.
chazzle
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