This is the first I've heard of this MAB's use in
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Posted On: 03/02/2021 11:28:32 AM
Re: Riztheinvestor #80419
This is the first I've heard of this MAB's use in Covid-19.
Does anyone have link to actual article? All news seems to be nonmedical discussions of article with more of a sales pitch tone than strict data.
Study included 83 subjects with 1:1 split. phase 2 only
Interesting that their placebo only had 22.5% mortality. All patients enrolled were hospitalized but I would doubt they were all in the sever/critical category -- my opinion but would need to read article to verify.
Ohm-20 any thoughts on MOA -- downstream of LL or completely dif MOA?
Nomenclature
LIGHT stands for "homologous to lymphotoxin, exhibits inducible expression and competes with HSV glycoprotein D for binding to herpesvirus entry mediator, a receptor expressed on T lymphocytes". In the cluster of differentiation terminology it is classified as CD258.
Function
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator ligand (HVEML). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.[6]
Does anyone have link to actual article? All news seems to be nonmedical discussions of article with more of a sales pitch tone than strict data.
Study included 83 subjects with 1:1 split. phase 2 only
Interesting that their placebo only had 22.5% mortality. All patients enrolled were hospitalized but I would doubt they were all in the sever/critical category -- my opinion but would need to read article to verify.
Ohm-20 any thoughts on MOA -- downstream of LL or completely dif MOA?
Nomenclature
LIGHT stands for "homologous to lymphotoxin, exhibits inducible expression and competes with HSV glycoprotein D for binding to herpesvirus entry mediator, a receptor expressed on T lymphocytes". In the cluster of differentiation terminology it is classified as CD258.
Function
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator ligand (HVEML). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.[6]
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