In the 2% of ALS patients with a SOD1 mutation ler
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Posted On: 02/21/2021 12:35:54 AM
In the 2% of ALS patients with a SOD1 mutation leronlimab may still offer hope. CCR5 blockade knocks down microglia activation.
https://www.frontiersin.org/articles/10.3389/...00594/full
Quote:
In addition, in transgenic mice, carrying SOD1 mutations, toxic effects to motor neurons by microglia activation were observed.
The microglia cells can carry out an important role in ALS progression since microglia activation can be observed before neuron loss in transgenic mice expressing human SOD1 mutants
https://www.frontiersin.org/articles/10.3389/...00594/full
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