Someone asked LL vs. Mav binding affinity to the r

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Someone asked LL vs. Mav binding affinity to the receptor, Mav binds more avidly and can even displace LL. From BP.

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Occupancy of CCR5 receptors by maraviroc was studied in HIV-1–infected patients and was found to be >80% just before readministration at a steady state. Five days after discontinuation of the drug, the receptors remained >60% occupied

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[https://academic.oup.com/cid/article/47/2/236/358070]https://academic.oup.com/cid/article/47/2/236/358070[/url]

With superior occupancy one would think it would have superior efficacy to leronlimab.

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At week 48, 67.3% maraviroc (=ART) recipients and 76.3% placebo (+ART) recipients achieved an undetectable viral load (VL <50 copies/mL; P=0.048).

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https://www.jwatch.org/na50863/2020/02/21/can...vanced-hiv