Two other potential's Ohm, one you had mentioned t

Two other potential's Ohm, one you had mentioned to me, and one I am curious about but seems like it might be similar to one chazzledazzle mentioned

First is Mast Cell Activation Syndrome which some researchers believe may be a part of severe covid/post covid

https://www.sciencedirect.com/science/article...1220307323

The other one I was also curious about is a condition a friend's daughter has long suffered with, Lymphedema

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361763/

While the root causes may not be fixed by leronlimab, couldn't the inflammatory response and secondary complications be controlled?

In particular, I thought this paragraph relates to leronlimab

Quote:

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Further, the irregular accumulation of immune mediators (cytokines and chemokines) in lymphedematous tissue could be an initiating factor promoting activation of LECs and immune cells (35). It is well-known that lymphatics can respond to immune mediators produced by macrophages, including TNF-α, IL-1β, and IFNγ (36), and are able to produce immune mediators which regulate macrophage function such as IL-6 and CCL21 (35, 37). It has also been shown that macrophages produce inducible nitric oxide synthase which causes a reduction of lymphatic vessel contraction (38) and thus may contribute to accumulation of tissue fluids and impairment of antigen transport to lymph nodes in lymphedema (Figure 1). In summary, it is likely that lymphatic activation perpetuates abnormal activation of macrophages, and visa-versa, which could contribute to immune dysfunction and abnormal inflammation in lymphedema.

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As always, thanks for all your contributions!