Quote:repost, I am sure.....Recent Advances Targeting CCR5 for Cancer and Its Role in Immuno-Oncology
July 2019
Abstract Experiments of nature have revealed the peculiar importance of the G-protein–coupled receptor, C-C chemokine receptor type 5 (CCR5), in human disease since ancient times.....
CCR5 is overexpressed in breast cancer (4, 5), gastric adenocarcinoma (24), prostate cancer (25), colorectal carcinoma (26, 27), melanoma (28), Hodgkin lymphoma (29), head and neck cancer (30), gastric cancer (31), esophageal cancer (32), pancreatic cancer (33), acute lymphocytic leukemia (33, 34), and other tumors (Fig. 1B). In analysis of >2,200 patients with breast cancer, >50% of patient's tumors were CCR5þ and >95% of triplenegative breast cancer (TNBC) were CCR5þ (4). Higher cytoplasmic CCR5 staining correlated with poor prognosis (5). CCR5 is induced by oncogenic transformation (Ha-Ras, c-Myc, ErbB2, and c-Src; ref. 4), DNA damage (5), and CCL5 stimulation. CCR5 receptor levels correlate with poor prognosis in breast cancer and gastric adenocarcinoma (5, 23, 24). Although CCR5 binds many ligands that are overexpressed in cancer, elevated levels of the ligand CCL5 (RANTES) indicate poor prognosis in breast cancer (35, 36), cervical cancer (36), prostate cancer (37), ovarian cancer (38), gastric cancer (23, 39), metastatic colorectal carcinoma response to regorafenib (40), and pancreatic cancer (33). Elevated level of CCL5 (RANTES) in tissues or plasma is indicative of unfavorable outcome in patients with melanoma, breast, cervical, prostate, gastric, or even pancreatic cancer (41–43).
https://cancerres.aacrjournals.org/content/ca...7.full.pdf
Read More: https://investorshangout.com/post/newpost/605...z6PvhWcBj9
Great post for Ohm20 to see -- if he hasn't already.repost,
Top 10 Most Recent News Articles
Hidden Fences: A Smarter Choice for Pet Owners?
The Case for Invisible Fences Man's best friend meets modern containment! Why are hidden fences gaining traction in households across Culpeper, VA, and beyond? Pet Containment Expert Lawrence Sowers spills some valuable insights into why so many are ditching traditional fences. Practical reasons abound, folks! Keeping the Yard Beautiful Who wants their landscaping ruined...
Continue Reading
Autoliv Snaps Up MCF Safety Belts to Boost Growth
Strategic Moves in Vehicle Safety Listen up! Autoliv is playing its cards right by snatching up Italy's MCF Safety Belts. Even for us with skin in the automotive game, it's clear why this matters. We're not talking just any acquisition, but one that steers Autoliv beyond conventional passenger cars. By grabbing MCF's niche expertise, Autoliv is showing it's ready to...
Continue Reading
Extreme Weather Survivors Rally for Change with 'Stolen Summers'
Lighting a Fire Under Complacency Elections often bring out the big dogs, but rarely do you see a grassroots campaign like Extreme Weather Survivors’ 'Stolen Summers' making such ripples. Rallying from New York to North Carolina and everywhere in between, this campaign has been a clarion call for communities ravaged by Mother Nature's fury. And let's face it, the...
Continue Reading
SlidesAI Launches Standalone Platform for Presentations
From Add-on to Standalone: SlidesAI's Big Leap You know what they say: time waits for no one, and that seems true in tech too. Those suit-and-tie presentation days? SlidesAI just took a swing at redefining them. Once a trusty sidekick locked into Google Slides, it's now captaining its own ship. Welcome to the SlidesAI standalone presentation platform—where AI meets your...
Continue Reading
Hippocratic AI's Polaris 6 Ultra Reshapes Healthcare AI
A Bold Move in Healthcare AI Imagine a world where your healthcare provider feels less like a machine and more like a human—a world where AI doesn't just regurgitate data but reads and reacts to your emotions in real-time. Enter Hippocratic AI’s latest creation: Polaris 6 Ultra. Billed as the first AI healthcare model with “bedside intuition,” this beast is saying...
Continue Reading
Waveform Debuts: Tech-Driven Cannabis Distribution Giant
Waveform's Grand Entry: A New Era in Cannabis Distribution Ever feel like the cannabis game needed a serious shake-up? Well, it's here. At the intersection of technology and distribution stands Waveform, the newly minted name for the company born from the merger of Kiva Sales & Service (KSS) and Petalfast. Underpinning this powerhouse is a tech-forward approach that's as...
Continue Reading
Levvy AI: Transforming Hidden Hours into Advisory Gold
Unlocking Hidden Potential: Levvy AI on the Scene Picture this: you're running an accounting shop and drowning in an ocean of endless tasks, manual entries, and those cursed follow-ups. That's probably the daily grind, right? Well, it looks like Levvy has decided to break those shackles. This company, based over there in Brooklyn, is rolling out these fancy Levvy AI...
Continue Reading
Northwind Backs Huge Office-to-Residential Overhaul
In the Heart of Midtown: A Major Overhaul I'm telling ya, if there's a piece of news that makes me sit up straight this morning over the breakfast bar, it's this colossal $231 million construction loan announcement by Northwind Group. They're turning 675 Third Avenue, a towering 32-story office behemoth smack in Midtown, into residential apartments. Right here in...
Continue Reading
Planning Your Pergola: DIY Backyard Transformation
Blueprint for a Backyard Upgrade Transforming a backyard isn't just about nailing down the aesthetics with a motorized pergola. The real magic is in thoughtful planning—right from the get-go. Whether you've got your sights set on the sleek FlexPatio motorized pergola kits or another setup, it all begins with a mental blueprint before a single speck of dirt is disturbed....
Continue Reading
D-Wave Faces Securities Fraud Class Action: Details Inside
D-Wave Quantum Inc. in Hot Water Well folks, looks like D-Wave Quantum Inc. (NASDAQ: QBTS) is knee-deep in a securities fraud class action lawsuit. This ain't just another day in the quantum computing trenches. We've got Kessler Topaz Meltzer & Check, LLP, a big player in securities litigation, rallying the troops here—a clear sign that this case is packing some hefty...
Continue ReadingTop 5 Most Recently Viewed Articles
Skyline Medical Faces High Market Pressure with POAI Low at $0.64
Skyline Medical Inc. Stock Reaches New Low In the face of a volatile market, Skyline Medical Inc. (POAI) has seen its stock price fall to a concerning 52-week low of $0.64. This sharp decline represents an 81.66% drop over the past year, revealing the significant challenges the company has encountered. Investors are keeping a close watch on POAI's efforts to stabilize...
Continue Reading
Foresight Diagnostics Validates CLARITY MRD Assay for DLBCL
Foresight Diagnostics Validates CLARITY MRD Assay for DLBCL Treatment Foresight Diagnostics, a notable player in the diagnostics industry, has shared compelling new findings regarding its CLARITY Minimal Residual Disease (MRD) assay. This groundbreaking information was revealed during a multicenter study focused on frontline Diffuse Large B-Cell Lymphoma (DLBCL). The...
Continue Reading
Surge in Medical Tricorder Demand Drives Market Toward Growth
Growing Demand for Medical Tricorders and Future Prospects The medical tricorder market is experiencing significant momentum, with a remarkable valuation of USD 3.7 billion in 2023. This industry is poised for substantial growth, projected to reach USD 6.3 billion by 2032. The compound annual growth rate (CAGR) expected from 2024 to 2032 is approximately 6.1%. The driving...
Continue Reading
Catalis Dental Lab Partners Broadens Reach with New Facility
Catalis Dental Lab Partners Expands with New Acquisitions Catalis Dental Lab Partners has reached two significant milestones in its expansion efforts. The company announced the acquisition of Revolution Dental Lab and the launch of a cutting-edge Digital Design Center focused on servicing dental professionals more effectively. Acquisition of Revolution Dental Lab As part...
Continue Reading
Pacific West Bancorp Reports Noteworthy Q2 Financial Achievements
Pacific West Bancorp Posts Strong Second Quarter Results Pacific West Bancorp (PWBK), the holding company of Pacific West Bank, recently disclosed its second quarter financial results, revealing a net income of $130 thousand or $0.05 per diluted share. This financial outcome underscores the company's commitment to its growth strategy, as they continue to strengthen their...
Continue Reading