CCL5 is Rantes. Same protein. There are some gramm
Post# of 155450
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Posted On: 04/28/2020 5:08:52 AM
Re: chazzledazzle #30449
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CCL5 is Rantes. Same protein. There are some grammatical problems in the following translation, but Rantes/CCL5 is a protein involved in binding to CCR5 receptor. In my laymen’s terms (bc I’m a layman), it’s involved in allowing this Virus to attach and take over our immune system.
Neither CCL5 (chemokine) or CCR5 (receptor) has any role in the virus binding to the ACE2 receptor.
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The IL-6 cytokine we’ve been hearing about, while a very significant thing, isn’t as key to the Leronlimab effect
IL-6 is one of the keys, CCL5 binding to CCR5 upregulates IL-6 and IL-6 is the most potent cytokine for inflammation. The action of leronlimab blocking CCL5 it downregulates IL-6 keeping the cytokine storm at bay.
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