Good evening to all.
I am having, as promised, my Buchanan's (more than one) after the great and satisfactory day …
Couldn't have been better. Not talking about money here. I don't know if you heard that I did. But in case you didn't here is the whole "main" enchilada (emphasis mine):
Dr. Bruce Patterson:
The implications are huge. Not sure if everybody understand how much meat is there and, I wouldn't like to comment now (hope you understand why) but if what Dr. Patterson is saying is true ...
To da moon !!!. Once more congratulations to all longs, you deserve it !!! This is to all of you
I am having, as promised, my Buchanan's (more than one) after the great and satisfactory day …
Couldn't have been better. Not talking about money here. I don't know if you heard that I did. But in case you didn't here is the whole "main" enchilada (emphasis mine):
Dr. Bruce Patterson:
Quote:It's real pleasure to be on this call but most importantly it's a pleasure to be able to reveal what we have discovered and how that could potentially help of this horrible endemic and get people back to work and save patients’ lives.
Most importantly we've heard a lot about IL-6 is being the key to the cytokine storm I am telling you today COVID-19 is a RANTES disease. RANTES is a protein that binds to CCR5 and elevated levels that are equivalent to an even greater than interleukin 6 both in mild to moderate patients and then critically ill patients. RANTES has also been attributed to renal failure, liver failure, and coagulation issues. So there is nothing that RANTES has it been involved in, it that makes sense because RANTES coordinates the movements of cells throughout the body.
Second treatment of Leronlimab in these patients brought IL-6 by 14 days to normal levels, which was truly amazing, and that combination of inhibiting the sequestration of macrophages in the lungs, and also, the change in the production of IL-6, the repolarization that we’ve heard about and changing macrophages away from pro-inflammatory phenotype. In addition, Leronlimab restored be immune cells in the horrible immune suppression so that by day 14 the CD4/CD8 ratio that were used also to measure immunosuppression in HIV AIDS were restored to normal over 14 days. Most importantly, and this was all we can hope for, because we knew that we blocked T-regulatory cells to inhibit the immune response as well as other factors, Leronlimab decreases plasma viral load.
We are the first to report the ability to quantify viruses in the plasma and this is the first report that this immune modulator non an anti-viral, is responsible for reduction in plasma virus as if it were an anti-viral. That is remarkable for one drug to restore the immune system and decrease the viral burden in these patients, that is what brings us big hope and big excitement about Leronlimab going forward in these trials. A cautionary aspect of that finding is that we have to be concerned about our blood supply.
Coronavirus now exists in blood, not just the lungs, and current testing of the blood supply, including units given to patients plasma has not been determined and is not been addressed appropriately; so these findings are dramatic, they are all very exciting and unreported in COVID infection, and the up-regulation of RANTES that accounts for a role in just about all the comorbidities in COVID infection and the use of Leronlimab our hope is that, in addition to restoring lung function, to also reduce the comorbidities in these patients.
The implications are huge. Not sure if everybody understand how much meat is there and, I wouldn't like to comment now (hope you understand why) but if what Dr. Patterson is saying is true ...
To da moon !!!. Once more congratulations to all longs, you deserve it !!! This is to all of you
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