For those interested on how macrophages work in lu

For those interested on how macrophages work in lung immunoregulatory tasks a very recent article (published 4 days ago).

https://immunology.sciencemag.org/content/5/4...56/tab-pdf

It seems that there are different classes of macrophages in the lungs. Alveolar macrophages AMs, which are large and round, and, newly identified nerve-and airway-associated macrophages, or NAMs (elongated with sprawling arms), that congregate at airways and interact with surrounding nerves.

AMs help to fight the virus while NAMs suppress inflammation and prevent tissue damage.

Quote:

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NAMs regulate inflammation in the lung both during steady state and after induction of inflammation. Considering the putative importance of these macrophages and given that we know little about these cells, our study will open new avenues of research and therapy with respect to respiratory infections and other inflammatory lung diseases. Furthermore, our results will prompt a reevaluation of our understanding of the role various macrophage subsets play in the lung during inflammatory conditions.

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Quote:

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We treated WT and NAMDTR mice with poly(I:C) after DT administration and analyzed the cytokine and chemokine production in lung tissue and bronchoalveolar lavage (BAL) fluid 8 hours after treatment. In the absence of NAMs, we observed a significant increase in proinflammatory cytokines and chemokines such as IL-6, CCL2, CCL3, and CCL5

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So our antagonist is trying to deal with both, CCL5 and reduces also IL-6