I mentioned concerns with crisper last year, what

I mentioned concerns with crisper last year, what could go wrong.

https://www.technologyreview.com/s/614235/rec...a-screwup/

Gene-edited cattle have a major screw up in their DNA.

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Food and Drug Administration scientists who had a closer look at the genome sequence of one of the edited animals, a bull named Buri, have discovered its genome contains a stretch of bacterial DNA including a gene conferring antibiotic resistance.

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Also news out this week discussing, after excepts of manuscript was released.

China gene-edited baby experiment 'may have created unintended mutations'
https://www.theguardian.com/science/2019/dec/...-mutations


Also very interesting read this morning, at least to me, there is one virus that is invincible to CRISPR

https://www.theatlantic.com/science/archive/2...us/603412/

A phage that resists all forms of the antiviral defense known as CRISPR has an unusual means of survival.

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It encapsulates its DNA inside a shell of protein, which it suspends inside itself with thin filaments. That’s exceptionally odd. The cells of animals and plants also house their DNA within a special compartment—the nucleus. But such compartments aren’t meant to exist in simpler cells, like those of bacteria. And they’re certainly not meant to exist in viruses, which some scientists don’t even regard as alive. And yet, here was a phage, packaging its DNA in something akin to a nucleus. Why?

Agard told Bondy-Denomy about the phage that surrounds its DNA in a shell. Bondy-Denomy told Agard about the phage that’s resistant to all forms of CRISPR. It slowly dawned on the duo that the viruses they were studying were closely related, and that the weird phenomena they had found were linked. CRISPR can’t destroy what it can’t reach, and the shell stops it from getting at the phage’s DNA. The phiKZ phage and its relatives don’t need to evolve countermeasures against each and every form of CRISPR when they have ways of excluding them all. “Proving it was the hard part,” Bondy-Denomy says. “That took a couple of years.”

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