Due to leronlimab allowing normal immune functions

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Due to leronlimab allowing normal immune functions and other drugs to still bind/function, would this potentially support keeping the disease from mutating to X4 or cancer from finding other pathways?

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Yes, the reason why is that the larger the population of viruses or tumor cells the greater the chance of a mutation beneficial to the organism.
Also the faster the kill off the less chance a beneficial mutation will develop and survive competition against its rivals. With a fully functional immune system aiding the fight it's much less likely to occur.