He mentioned a switch twice, specifically pro 140

He mentioned a switch twice, specifically pro 140 blocking ccl5( rantes) which is why I have been looking at rantes stuff. I believe he has found that switch allows drugs to work again and we know that switch turns on the cancer fighting ability.
It sounded to me he has been testing this, and is confirming these possibilities, which is why he is so excited about the potential. The drug comment made me think he might have even be confirming using those specific drugs, just a guess though.




35:47 it's about ccr5 on certain immune cells
35:51 that that control the tumor okay so
35:54 there's two eight billion dollar-a-year
35:56 drugs called opdivo and keytruda
36:00 made by Merck and BMS that bring back
36:03 your own immune system to fight off the
36:05 tumor but you know what happens after
36:08 three to six months they stopped working
36:10 why do they stop working well this whole
36:13 new wave of cells comes in to shut that
36:17 immune response off that's part of the
36:19 elegance of our body in controlling you
36:23 know a immune response gone awry right
36:26 but in cancer we want the immune
36:28 response to go awry right those immune
36:32 cells called T reg cells, that come in
36:34 and supposedly shut off the light switch
36:37 that opdivo and keytruda have turned back
36:40 on, express ccr5. So if we get pro 140 it
36:45 can block those cells from coming in and
36:48 shutting off the immune response that
36:50 you just spent two hundred thousand
36:52 dollars a year to bring back in the
36:54 patient it's a tremendous opportunity
36:56 this is a immuno oncology drug it is it
37:01 always has been and you know it hasn't
37:04 come to the forefront until just
37:06 recently now that we have more
37:08 information on how this immune response
37:11 against tumors is is regulated the other
37:14 thing that pro 140 does is it
37:16 reprogrammed
37:17 a cell called a macrophage think of
37:20 pac-man that little guy that goes around
37:22 and gobbles up little things on the
37:24 computer game
37:25 well macrophages come and gobble up
37:28 tumor cells normally right but when
37:31 they're when they're blocked by CCL5
37:34 which is a protein made by t-cells they
37:38 don't go and gobble up the tumor cells
37:39 when you block with pro 140 those
37:43 macrophages are now active against the
37:45 tumor again so this is extremely
37:49 exciting immuno Oncology drug and you
37:53 know what I think the field is just
37:54 starting to realize it it's the
37:56 quarterback of cells moving in the body
37:59 to where they need to be and prolong for
38:02 taking control of that and now we have a
38:05 diagnostic that says this drug is going
38:07 to bind exactly

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