Investors Hangout Stock Message Boards Logo
  • Mailbox
  • Favorites
  • Boards
    • The Hangout
    • NASDAQ
    • NYSE
    • OTC Markets
    • All Boards
  • Whats Hot!
    • Recent Activity
    • Most Viewed Boards
    • Most Viewed Posts
    • Most Posted
    • Most Followed
    • Top Boards
    • Newest Boards
    • Newest Members
  • Blog
    • Recent Blog Posts
    • Recently Updated
    • News
    • Stocks
    • Crypto
    • Investing
    • Business
    • Markets
    • Economy
    • Real Estate
    • Personal Finance
  • Market Movers
  • Interactive Charts
  • Login - Join Now FREE!
  1. Home ›
  2. Stock Message Boards ›
  3. Stock Boards ›
  4. CytoDyn Inc (CYDY) Message Board

Patterson: 32:30 thank you Nader it's 32:38

Message Board Public Reply | Private Reply | Keep | Replies (4)                   Post New Msg
Edit Msg () | Previous | Next


Post# of 154858
(Total Views: 663)
Posted On: 09/14/2019 2:58:53 PM
Avatar
Posted By: trding
Re: trding #8116
Patterson:
32:30 thank you Nader it's
32:38 certainly a pleasure to be here talking
32:40 about one of my favorite subjects I
32:43 think it was a face that I met Nader
32:46 because I've spent 22 years working on
32:48 ccr5 first 15 in HIV funded by the
32:54 National Institutes of Health the last
32:56 five in the immuno oncology space
32:58 through my company incellDX the
33:02 important point about
33:03 ccr5 you see a lot of different in the
33:05 patience here you might say how can it
33:07 be effective against all of these
33:09 different indications well the fact is
33:12 ccr5 inhibitor Pro 140 it's like the
33:16 quarterback of the immune system so if
33:19 you look at any of those indications
all
33:21 of them are driven by immune
33:23 responsiveness or a lack of immune
33:26 responsiveness and ccr5 is critical in
33:29 both of those contexts in terms of our
33:33 deal that we signed we indeed have
33:35 already ordered from CytoDyn our first
33:39 lot of pro 140 label with a fluorescent
33:43 dye so that we can sting tissues and
33:46 cells and say which cancer cells and the
33:49 immune cells associated with it and
33:51 which cells that HIV infects are
33:54 actually occupied by Pro 140 we actually
33:58 have the ideal tool to go to the FDA and
34:00 say listen this drug is working and an
34:03 irrespective of the viral load we know
34:06 this drug is working some of the things
34:08 that we're seeing on the ongoing HIV
34:11 trials are fascinating because Pro 140
34:15 acts on the cells that HIV infects and
34:18 protects them from being infected the
34:22 hallmark of HIV is the destruction of
34:24 the immune system as we all know and
34:26 AIDS right if you preserve the immune
34:30 system you're fine you have a competent
34:34 immune system that's what pro 140 does
34:36 it doesn't go in and inhibit the virus
34:40 like some of these other drugs do which
34:43 happen to be a lot more toxic than ccr5
34:46 but it blocks additional cells from
34:49 being infected which is really the
34:51 hallmark that's the goal of what
34:53 everybody should be looking for a good
34:55 analogy is I relate to you trying to
34:57 start a fire on your grill and you have
35:00 no charcoal but you have lighter fluid
35:02 so sometimes the lighter fluid will
35:05 light which I relate to an increase in
35:07 viral load but there's nothing to
35:10 propagate the fire so that you can cook
35:13 your hamburgers
35:13 right leronlimab
35:16 blocks the key cells that propagate
35:19 infection you need to prolonged
35:21 increases of viral load that's the
35:24 message that has to go to the FDA that
35:26 this drug is completely occupying the
35:29 receptors that it needs to occupy and
35:31 it's blocking virus from binding to
35:33 uninfected cells and preserving the
35:36 immune system that's where we all want
35:39 to be
and in cancer ccr5 has been around
35:43 for a long time and it's not about ccr5
35:46 on the tumor
35:47 it's about ccr5 on certain immune cells
35:51 that that control the tumor okay so
35:54 there's two eight billion dollar-a-year
35:56 drugs called opdivo and keytruda
36:00 made by Merck and BMS that bring back
36:03 your own immune system to fight off the
36:05 tumor but you know what happens after
36:08 three to six months they stopped working
36:10 why do they stop working well this whole
36:13 new wave of cells comes in to shut that
36:17 immune response off that's part of the
36:19 elegance of our body in controlling you
36:23 know a immune response gone awry right
36:26 but in cancer we want the immune
36:28 response to go awry right those immune
36:32 cells called T reg cells that come in
36:34 and supposedly shut off the light switch
36:37 that opdivo and keytruda have turned back
36:40 on Express ccr5 so if we get pro 140 it
36:45 can block those cells from coming in and
36:48 shutting off the immune response that
36:50 you just spent two hundred thousand
36:52 dollars a year to bring back in the
36:54 patient it's a tremendous opportunity
36:56 this is a immuno oncology drug it is it
37:01 always has been and you know it hasn't
37:04 come to the forefront until just
37:06 recently
now that we have more
37:08 information on how this immune response
37:11 against tumors is is regulated the other
37:14 thing that pro 140 does is it
37:16 reprogrammed
37:17 a cell called a macrophage think of
37:20 pac-man that little guy that goes around
37:22 and gobbles up little things on the
37:24 computer game
37:25 well macrophages come and gobble up
37:28 tumor cells normally right but when
37:31 they're when they're blocked by CCL 5
37:34 which is a protein made by t-cells they
37:38 don't go and gobble up the tumor cells
37:39 when you block with pro 140 those
37:43 macrophages are now active against the
37:45 tumor again so this is extremely
37:49 exciting immuno Oncology drug and you
37:53 know what I think the field is just
37:54 starting to realize it it's the
37:56 quarterback of cells moving in the body
37:59 to where they need to be and prolong for
38:02 taking control of that and now we have a
38:05 diagnostic that says this drug is going
38:07 to bind exactly
in the past we've been
38:11 looking at ccr5 expression with antibody
38:13 bodies made by Dickinson and
38:15 other companies the problem is that
38:18 doesn't bind to the exact site that Pro
38:20 140 does so what we did in our deal is
38:23 we made sure that when we're doing
38:25 Diagnostics to see if there's a
38:27 candidate for pro 140 we're going to use
38:30 the actual drug as a diagnostic it's
38:34 elegant it's extremely elegant and it's
38:37 going to be much more specific and
38:39 accurate in defining the patients that
38:41 are going to respond and at the end of
38:43 the day we're all going to benefit from
38:45 that so I can't tell you how excited I
38:48 am about this and when you look at these
38:50 boards and all the different indications
38:51 it's easy to say well we're all over
38:53 the place in reality we're not what
38:56 we're just doing is taking advantage of
38:58 all the different disease states that
39:00 ccr5 is active in and this drug has
39:04 applications for all of those yet we
39:07 need to focus on the ones that are at
39:09 hand and get the HIV applications
39:12 approved but after that the pipeline
39:15 after that they'll just keep feeding
39:17 keep feeding the utility of pro 140 is
39:21 extremely excited really really exciting
39:25 both for the emulation standpoint and a
39:28 viral logic standpoint and again
39:30 for my work at Northwestern first and
39:33 then at Stanford this is what I spent my
39:35 life doing and finally this is coming to
39:38 the forefront so and I'm happy to answer
39:40 any questions any time show you any data
39:44 that we have internally that may not be
39:46 out to the masses or out to the FDA yet
39:48 because it is really really exciting
39:51 when I'm looking at this data coming off
39:53 our machines every single day there's
39:56 not a single day where I can't wait to
39:58 get into work and see that
so we
40:09 definitely answer any question


(5)
(0)




CytoDyn Inc (CYDY) Stock Research Links


  1.  
  2.  


  3.  
  4.  
  5.  






Investors Hangout

Home

Mailbox

Message Boards

Favorites

Whats Hot

Blog

Settings

Privacy Policy

Terms and Conditions

Disclaimer

Contact Us

Whats Hot

Recent Activity

Most Viewed Boards

Most Viewed Posts

Most Posted Boards

Most Followed

Top Boards

Newest Boards

Newest Members

Investors Hangout Message Boards

Welcome To Investors Hangout

Stock Message Boards

American Stock Exchange (AMEX)

NASDAQ Stock Exchange (NASDAQ)

New York Stock Exchange (NYSE)

Penny Stocks - (OTC)

User Boards

The Hangout

Private

Global Markets

Australian Securities Exchange (ASX)

Euronext Amsterdam (AMS)

Euronext Brussels (BRU)

Euronext Lisbon (LIS)

Euronext Paris (PAR)

Foreign Exchange (FOREX)

Hong Kong Stock Exchange (HKEX)

London Stock Exchange (LSE)

Milan Stock Exchange (MLSE)

New Zealand Exchange (NZX)

Singapore Stock Exchange (SGX)

Toronto Stock Exchange (TSX)

Contact Investors Hangout

Email Us

Follow Investors Hangout

Twitter

YouTube

Facebook

Market Data powered by QuoteMedia. Copyright © 2025. Data delayed 15 minutes unless otherwise indicated (view delay times for all exchanges).
Analyst Ratings & Earnings by Zacks. RT=Real-Time, EOD=End of Day, PD=Previous Day. Terms of Use.

© 2025 Copyright Investors Hangout, LLC All Rights Reserved.

Privacy Policy |Do Not Sell My Information | Terms & Conditions | Disclaimer | Help | Contact Us