I try to add what we know about CCR5 and cancers .

I try to add what we know about CCR5 and cancers ...and Leronlimab and cancers ...
Please add or correct anything here ...


1.) CCR5 makes cancers cells metastasize ( The GPS effect )

.....by calcium channel signaling on CCR5 on cancer cells, which is important to produce metastasis..
Leronlimab is blocking this calcium channel signaling .

2 .) CCR5 activate DNA mechanism ,

....... cancer cells recuperate much faster after chemotherapy ,
becoming resistant to treatment ,
Leronlimab is blocking that.

3. ) Regulate body anti-tumor response..

........A---there is polarization of macrophages with CCR5 inhibitors.
process by witch macrophages adopt different functional programs..

M0 -- uncommitted macrophages.
M1 --classically activated , producing pro-inflammatory process , and irritation of immune response.
M2 --alternatively activated , turning on constructive process , like wound healing , producing anti-inflammatory cytokines.

All this help to produce necrosis in tumor cells.

..........B.--From Dr Patterson we also know that CCR5 is expressed on the population of immune cells call T regulatory cells which inhibits response to cancers.


4. ) Recently from Dr Lindner pre-clinical study in colon cancer we learned that Leronlimab inhibits angiogenesis , and is working on solid tumors with both high and low CCR5 expression.