Although the specific information given is somewha

Although the specific information given is somewhat limited in this article, one of the things which caught my eye, other than Myc downregulation, was the upregulation of the NF-kB pathway. From a biochemical perspective, SUMOylation (by SAE 1/2) of an inhibitor protein strongly inhibits NF-kB. If genes in this pathway are upregulated, it could be inferred that SAE 1/2 are either downregulated. This could be huge because in the presence of Myc hyper activation, as is the case in many tumors, if SAE’s, particularly SAE2 is down regulated, this has been shown to lead to mitotic failure and cell death in Myc driven tumors. VERY INTERESTING. Consider the article below

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059214/