MANF - read this from latest article I posted:
Post# of 30066
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Posted On: 02/06/2017 2:11:39 PM
MANF - read this from latest article I posted:
Numerous ophthamic diseases, such as diabetic retinopathy (Ikesugi et al., 2006; Li et al., 2009), glaucoma (Zode et al., 2015), retinal detachment (Liu et al., 2010; Zhu et al., 2013), and age-related macular degeneration (Li et al., 2008; Libby and Gould, 2010), are associated with neuronal apoptosis and ERS. Reducing ERS could be an underlying therapeutic strategy, where ERS manipulation could slow the progress of retinal degeneration and promote the survival of retinal neurons (Doh et al., 2010; Li et al., 2012, 2014). Studies have shown that MANF is a secretory protein and that ERS could induce its expression and secretion (Mizobuchi et al., 2007; Apostolou et al., 2008). It can be differently regulated by epileptic and ischemic insults in the rodent brain and heart (Apostolou et al., 2008; Lindholm et al., 2008; Tadimalla et al., 2008). Besides, large studies indicate that MANF can not only protect cultured nigral dopaminergic neurons and suppress cell proliferation and ERS-induced cell death, but also can affect cell morphology and size in non-neuronal cells (Petrova et al., 2004; Lindholm et al., 2007; Airavaara et al., 2009; Palgi et al., 2009; Voutilainen et al., 2009; Yu et al., 2010; Commissiong, 2012; Shen et al., 2012; Zhao et al., 2013; Yang et al., 2014; Cordero-Llana et al., 2015; Liu et al., 2015). Moreover, recently reported on science displayed that intravitreal injection recombinant MANF could promote alternative activation of innate immune cells, enhance neuroprotection and tissue repair, and improve the success of photoreceptor replacement therapies in the retina (Neves et al., 2016). These results implying that MANF may have a close relationship with the physical and pathological regulation of the retina. Further in-depth analysis of the expression and distribution of MANF in the retina and ON will provide more information and a basis for further studies about the effect of MANF in tissues and MANF could thus serve as a treatment modality for ophthalmic diseases in the immediate future.
Numerous ophthamic diseases, such as diabetic retinopathy (Ikesugi et al., 2006; Li et al., 2009), glaucoma (Zode et al., 2015), retinal detachment (Liu et al., 2010; Zhu et al., 2013), and age-related macular degeneration (Li et al., 2008; Libby and Gould, 2010), are associated with neuronal apoptosis and ERS. Reducing ERS could be an underlying therapeutic strategy, where ERS manipulation could slow the progress of retinal degeneration and promote the survival of retinal neurons (Doh et al., 2010; Li et al., 2012, 2014). Studies have shown that MANF is a secretory protein and that ERS could induce its expression and secretion (Mizobuchi et al., 2007; Apostolou et al., 2008). It can be differently regulated by epileptic and ischemic insults in the rodent brain and heart (Apostolou et al., 2008; Lindholm et al., 2008; Tadimalla et al., 2008). Besides, large studies indicate that MANF can not only protect cultured nigral dopaminergic neurons and suppress cell proliferation and ERS-induced cell death, but also can affect cell morphology and size in non-neuronal cells (Petrova et al., 2004; Lindholm et al., 2007; Airavaara et al., 2009; Palgi et al., 2009; Voutilainen et al., 2009; Yu et al., 2010; Commissiong, 2012; Shen et al., 2012; Zhao et al., 2013; Yang et al., 2014; Cordero-Llana et al., 2015; Liu et al., 2015). Moreover, recently reported on science displayed that intravitreal injection recombinant MANF could promote alternative activation of innate immune cells, enhance neuroprotection and tissue repair, and improve the success of photoreceptor replacement therapies in the retina (Neves et al., 2016). These results implying that MANF may have a close relationship with the physical and pathological regulation of the retina. Further in-depth analysis of the expression and distribution of MANF in the retina and ON will provide more information and a basis for further studies about the effect of MANF in tissues and MANF could thus serve as a treatment modality for ophthalmic diseases in the immediate future.
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