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Wolfram Syndrome: Diagnosis, Management, and Treat

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Post# of 30065
Posted On: 04/28/2016 4:50:17 AM
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Posted By: redspeed
Re: freegriff #23368
Wolfram Syndrome: Diagnosis, Management, and Treatment
Fumihiko Urano


Regenerative Therapy and Gene Therapy for Wolfram
syndrome

Our first goal is to stop the progression of Wolfram syndrome
using FDA-approved drugs or novel small molecules
targeting the ER. In parallel, we need to figure out a
way to replace damaged tissues, such as pancreatic β cells
and retinal cells, in patients with Wolfram syndrome. Rapid
progress in the field of regenerative medicine may
make this possible in the near future [42] (Fig. 2). Our
strategy is to create induced pluripotent stem (iPS) cells
using patients’ skin cells, correct WFS1 gene mutations
with genome editing technology, and differentiate these
iPS cells into insulin-producing β cells, retinal cells, and
neurons for transplantation [43•]. We are currently using
the Clustered Regularly Interspaced Short Palindromic
Repeats (CRISPR) technology. We are also testing if mesencephalic
astrocyte-derived neurotrophic factor (MANF),
a regeneration factor purified from astrocytes, can prevent
cell death and activate the proliferation of remaining β
cells, neurons, and retinal ganglion cells by leveraging
our natural ability to regenerate damaged tissues


http://www.wolframsyndrome.co.uk/docs/2016_Ur...tesRep.pdf


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