Absolutely agree, the least you can take of any dr

Absolutely agree, the least you can take of any drug, the better. Maybe they are seeing varying efficacy depending on dose, and that's why they put that "optimization" comment in. I wish I could remember what company it was that rushed to put out their data, and didn't separate the low-dose arms from the rest of the clinical trial, so people jumped to the conclusion that their stuff didn't work when in fact it DID work, just not a low doses. Torpedoed the stock.