No problem, biodoc. MDM2 is usually overexpressed
Post# of 72436
http://mcr.aacrjournals.org/content/1/14/1001/F1.large.jpg
http://mcr.aacrjournals.org/content/1/14/1001.full.html
BTW, are you as excited about the planning of the ulcerative proctitis PoC trial as I am?
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Quote:
sox, thanks for the outstanding explanation. Question, if the genes are turned on and functional p53 proteins are available for a short period of time, and the MDM2 complex is only briefly disrupted, what effect would you anticipate with more prolonged (continuous) exposure to Kevetrin? Perhaps the equivalent of a protective reboot? TIA and sorry for my lack of involvement earlier- long day at work...
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