Prospects of Neurotrophic Factors for Parkinson's
Post# of 30028
Posted On: 07/17/2015 1:25:22 AM
Prospects of Neurotrophic Factors for Parkinson's Disease: Comparison of Protein and Gene Therapy - 2015 Jul 15. [Epub ahead of print]
Dr. Andrii Domanskyi, Prof. Mart Saarma, Dr. Mikko Airavaara
Neurotrophic factors (NTFs) hold a great potential as therapeutic agents in the treatment of neurodegenerative conditions, including Parkinson’s disease (PD), where the progressive loss of dopamine neurons in the substantia nigra pars compacta (SNpc) causes severe motor symptoms. There is extensive evidence that in preclinical animal models of PD NTFs are both neuroprotective and neurorestorative. Particularly glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte derived neurotrophic factor (MANF) have shown great potential to restore dopamine neurocircuitry .
http://www.ncbi.nlm.nih.gov/pubmed/26176331
Dr. Andrii Domanskyi, Prof. Mart Saarma, Dr. Mikko Airavaara
Neurotrophic factors (NTFs) hold a great potential as therapeutic agents in the treatment of neurodegenerative conditions, including Parkinson’s disease (PD), where the progressive loss of dopamine neurons in the substantia nigra pars compacta (SNpc) causes severe motor symptoms. There is extensive evidence that in preclinical animal models of PD NTFs are both neuroprotective and neurorestorative. Particularly glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte derived neurotrophic factor (MANF) have shown great potential to restore dopamine neurocircuitry .
http://www.ncbi.nlm.nih.gov/pubmed/26176331
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