BACKGROUND OF THE INVENTION The small molecule
Post# of 30028
Posted On: 01/08/2015 5:39:07 PM
Re: brickbybrick #14570
Quote:Crap!! I suppose this means the hundreds of posts about small molecules begins all over again. Fortunately, I've used the ignore feature to my advantage.
BACKGROUND OF THE INVENTION
The small molecule ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine) is a selective inhibitor of cyclic nucleotide phosphodiesterases (PDEs) 3A, 4, 10A1 and 11A1 (Gibson et al., Eur J Pharmacol 538: 39-42, 2006). Ibudilast also acts as a leukotriene D4 antagonist, an anti-inflammatory, a PAF antagonist, and a vasodilatory agent (Thompson Current Drug Reports). Ibudilast is thought to exert a neuroprotective role in the central nervous system of mammals, presumably via suppression of the activation of glial cells (Mizuno et al., Neuropharmacology 46: 404-411, 2004).
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