Here's what I could find about MANF Signaling J
Post# of 30028
July 18, 2014 - Amarantus Discusses New Independent Peer-Reviewed Research Papers on MANF
http://globenewswire.com/news-release/2014/07...-MANF.html
"Mechanism-of- action: Academic research groups are increasingly picking up research on MANF and advance our understanding of its mechanism of action with important implications to clinical development. Previously known effects of MANF on apoptosis are understood at increasing level of detail (5) and MANF signaling is started to being elucidated by demonstration of MANF-induced activation of PKC signaling (4). Finally, protein engineering studies continue to advance our understanding of the essential elements of MANF's protein structure for its function (6)."
Where Amarantus comes into play if the body isn't going to produce any extra MANF naturally for whatever reason.