CTIX News 08/10/2014 18:52:36 $CTIX
No kidding. Went to church for a few hours and what the heck has been going on around here? Now we have Dr george too? Good grief..............
Not criticizing you by any means but it. Was just ten eleven twelve that emailed df for a friend in Pennsylvania that found out about wait list. Was confirmed by your cited email and a poster on a. Breast cancer board.
Tomorrow market is open and we can get back to business of share price. Thank goodness
Gov
Check asco it was ten eom gov
That guest should be careful for what they wish for...... We are on borrowed time here in FL, eight years without a direct hit, at some point that will change. While weather is fascinating, no desire to see a Cat 2 or higher up close, I would be long gone before that if I lived right on the coast and in the storm surge zone....
I did not mean to say in absolutes. I was simply trying to point out the significance of multiple cycles. Dr. Jorgensen also stressed this point at Biotech Showcase.
Quote:
There are so many factors at play that it is ridiculous at this point to speak in absolutes.
Actually there is a waiting list for the Kevetrin trial. A poster here called DF and was told about the waiting list. Dr. Menon also said he does not expect a shortage of patients. Of course not everyone qualifies. Karen’s friend is an example.
Quote:
If things were so black and white there would be many more patients lining up for Kevetrin and many more investors as well, which there aren't.
As one guest put it, I paid for a full hurricane and this is all I got?
Big Island didn't fair as well as Oahu. Sadly, the occupants of a car perished trying to reach safety crossing a storm swollen stream.
Quote:
BK I hope you faired well in the recent storms in Hawaii,
Good Luck and GOD Bless......BUT pleeeeeease...enough already...
http://www.youtube.com/watch?v=d8cpkwPAbY0
GIDDDDDDDY UP & GOOOOOOOOOOOOOOOOOOOOOOO CTIX !
I am pretty sure the K trial starting dosage was 10mg/m2, not 15mg/kg
Hi rnn256, I agree with your last paragraph, we do need to take some of these guidelines with a grain of salt. If converting a mouse dose to a HED was simple in terms of determining what the anticipated efficacy should be when comparing efficacy in the mouse to humans, there would be would be few drug failures. Obviously that is not the case. The allometric scaling approach has limitations on the types of drug being tested and factors such as how highly protein bound the drug it, biliary vs renal excretion mechanisms and binding sites all come in to play as noted in the Sharma and McNeill paper.
At the end of the day we are placing faith in Dr. Menon's judgment and that's ok with me. He has a wonderful track record and I think his veterinary background also provides him with valuable insight when it comes to drug effects on differing species. My gut feeling tells me he is a driven "lab geek" who has special clinical skills (the lab geek reference is meant as a compliment). Hopefully we will have our confirmation in early 2015 (although another cohort or 2 would be fine with me). In closing perhaps what the underlying tone of this thread is defining what realistic expectations are. Speaking for myself, I cringe when I see some saying Kevetrin will be the cure for Cancer. While I would love to be wrong, I think it more accurately should be said that Kevetrin will cure some of cancer, very big difference but still a fabulous outcome that we all want at the end of the day for those suffering with cancer. I hope my comments today were not viewed as being a doubting Debby or negative in my hopes for Kevetrin. Time to go finish mowing my lawn in between the afternoon showers in FL. BK I hope you faired well in the recent storms in Hawaii, many years ago my sister lived on Oahu and I spent a summer there between by junior and senior years in high school (Rainbow Towers, Waikiki, I won't say how long ago.....) lots of beauty there.
George, just wondering why you repeatedly bring up the number 200 mg/kg but ignore Dr. Menon’s opinion that the efficacy range is 100-200 mg/m2 in humans? You think K will be a breakthrough drug, but the current dosage is nowhere near your magic number of 200 mg/kg. How is it possible then? Dr. Menon said he expects the MTD to be near, and yes, he told some posters in person after a conference. I tend to believe him because he has been right so far. He said P should convert to abacavir and he was right. He said MTD should be cohort 5-9 and he was right again. If DLT occurs in cohort 8 (not likely at this point) then cohort 9 is MTD. Whether you believe him or not is up to you of course.
Quote:
The dosage in humans is no where near 200 mg/kg.
Thank you all. So informative . c ya at 100 a share. Eom
This is by far the BEST board on this pathetic website ...eom
Based in the xenograft models K (200 mg/kg) proved to be more effective than paclitaxel (22 mg/Kg)
With regards to paclitaxel dosing:
Activity for paclitaxel 135 mg/m2 and 200 mg/m2 by 1-hour infusion every 3 weeks in patients with NSCLC, with minimal myelosuppression and the suggestion of a dose-response relationship, has been reported. In November 1994, we initiated a phase II trial in patients with advanced, measurable, chemotherapy-naive NSCLC using paclitaxel 175 mg/m2 given in 1 hour, and carboplatin dosed to a fixed target area under the concentration-time curve of 7.5 every 3 weeks. In the absence of grade 4 myelosuppression, paclitaxel was escalated on an intrapatient basis by 35 mg/m2 per cycle to a maximum dose of 280 mg/m2 by cycle 4.
Kevetrin:
The dosing was been increased approximately 33 percent from the seventh cohort to 215 mg/m2.
At the end of day models are just guidelines to be taken with a grain of salt and maybe because of K very short 1/2 life and non-genotoxic properties this will allow it to dose patients more frequently, maybe the MTD is still far away . But I see your point with regards to efficacy vs current dosing escalation.
That is a sweet looking flag on the 3 year chart. Thanks for that visual. Breakout to the upside could be imminent and swift.
I'm done with you, seeker of truth. What a load of crap. Nothing like ignoring all evidence to the contrary.
Your post is not clear.
Please, repost in a more coherent form.
What exactly are you saying about how the results from the preclinical posters for animal studies performed a 200 mg/kg relate to the current 215 mg/sq m human phase I trial. Should we expect similar results?
What results do you expect from the current 215 mg/sq m dose in humans???
Good luck and GOD bless,
George
I don't know if there's anything untruthful in that post and I don't care.
Any value to the topics you introduced ended after your first two or three posts.
At this point, we really don't care anymore. Just... let... it... go.......
Yes, the assumption that human equivalency in tumor growth delay is simply dependent on a 200 mg/kg dose shown in mouse studies, and using that number as the benchmark for expectations. That is not truthful.
Quote:
Kevetrin may be a good combination with chemotherapy and/or radiation.
The dosage in humans is no where near 200 mg/kg.
Stop the bullshit challenges. I'm only pointing out that using body weight, or even BSA, for converting to HED for other than starting dose is much more complicated than using Baur's simple formula. The misapplication of that simplistic conversion has caused much confusion over the years. The article I referenced points to exactly that problem.
I challenge you, since you are a seeker of truth, to enter a Ph.D. program and seek the truth regarding formulations for HED. It's a wide open field of study.
Please note that I am ignoring your insult "Now that you seem to be willing to logically and intelligently pursue the truth..."
Can anyone find anything untruthful in this post???
Do not expect miracles from Kevetrin
Limit your expectations for the Kevetrin Phase I trial to the realistic goal of finding a safe MTD that shows promise when used in combination with chemotherapy and/ or radiation.
For example, Avastin was not approved until it showed promise when used in combination with chemotherapy for colorectal cancer. Avastin has since made $BILLIONS in sales and is used as a treatment in combination with chemotherapy and/or radiation for a wide variety of cancers. Expect similar results for Kevetrin.
http://www.fda.gov/newsevents/newsroom/pressa...108252.htm
Kevetrin may be a good combination with chemotherapy and/or radiation.
The dosage in humans is no where near 200 mg/kg.
http://cellceutix.com/wp-content/uploads/pdfs...-11x17.pdf
http://cellceutix.com/wp-content/uploads/pdfs...0FINAL.pdf
Good luck and GOD bless,
George
No kidding. Went to church for a few hours and what the heck has been going on around here? Now we have Dr george too? Good grief..............
Not criticizing you by any means but it. Was just ten eleven twelve that emailed df for a friend in Pennsylvania that found out about wait list. Was confirmed by your cited email and a poster on a. Breast cancer board.
Tomorrow market is open and we can get back to business of share price. Thank goodness
Gov
Check asco it was ten eom gov
That guest should be careful for what they wish for...... We are on borrowed time here in FL, eight years without a direct hit, at some point that will change. While weather is fascinating, no desire to see a Cat 2 or higher up close, I would be long gone before that if I lived right on the coast and in the storm surge zone....
I did not mean to say in absolutes. I was simply trying to point out the significance of multiple cycles. Dr. Jorgensen also stressed this point at Biotech Showcase.
Quote:
There are so many factors at play that it is ridiculous at this point to speak in absolutes.
Actually there is a waiting list for the Kevetrin trial. A poster here called DF and was told about the waiting list. Dr. Menon also said he does not expect a shortage of patients. Of course not everyone qualifies. Karen’s friend is an example.
Quote:
If things were so black and white there would be many more patients lining up for Kevetrin and many more investors as well, which there aren't.
As one guest put it, I paid for a full hurricane and this is all I got?
Big Island didn't fair as well as Oahu. Sadly, the occupants of a car perished trying to reach safety crossing a storm swollen stream.
Quote:
BK I hope you faired well in the recent storms in Hawaii,
Good Luck and GOD Bless......BUT pleeeeeease...enough already...
http://www.youtube.com/watch?v=d8cpkwPAbY0
GIDDDDDDDY UP & GOOOOOOOOOOOOOOOOOOOOOOO CTIX !
I am pretty sure the K trial starting dosage was 10mg/m2, not 15mg/kg
Hi rnn256, I agree with your last paragraph, we do need to take some of these guidelines with a grain of salt. If converting a mouse dose to a HED was simple in terms of determining what the anticipated efficacy should be when comparing efficacy in the mouse to humans, there would be would be few drug failures. Obviously that is not the case. The allometric scaling approach has limitations on the types of drug being tested and factors such as how highly protein bound the drug it, biliary vs renal excretion mechanisms and binding sites all come in to play as noted in the Sharma and McNeill paper.
At the end of the day we are placing faith in Dr. Menon's judgment and that's ok with me. He has a wonderful track record and I think his veterinary background also provides him with valuable insight when it comes to drug effects on differing species. My gut feeling tells me he is a driven "lab geek" who has special clinical skills (the lab geek reference is meant as a compliment). Hopefully we will have our confirmation in early 2015 (although another cohort or 2 would be fine with me). In closing perhaps what the underlying tone of this thread is defining what realistic expectations are. Speaking for myself, I cringe when I see some saying Kevetrin will be the cure for Cancer. While I would love to be wrong, I think it more accurately should be said that Kevetrin will cure some of cancer, very big difference but still a fabulous outcome that we all want at the end of the day for those suffering with cancer. I hope my comments today were not viewed as being a doubting Debby or negative in my hopes for Kevetrin. Time to go finish mowing my lawn in between the afternoon showers in FL. BK I hope you faired well in the recent storms in Hawaii, many years ago my sister lived on Oahu and I spent a summer there between by junior and senior years in high school (Rainbow Towers, Waikiki, I won't say how long ago.....) lots of beauty there.
George, just wondering why you repeatedly bring up the number 200 mg/kg but ignore Dr. Menon’s opinion that the efficacy range is 100-200 mg/m2 in humans? You think K will be a breakthrough drug, but the current dosage is nowhere near your magic number of 200 mg/kg. How is it possible then? Dr. Menon said he expects the MTD to be near, and yes, he told some posters in person after a conference. I tend to believe him because he has been right so far. He said P should convert to abacavir and he was right. He said MTD should be cohort 5-9 and he was right again. If DLT occurs in cohort 8 (not likely at this point) then cohort 9 is MTD. Whether you believe him or not is up to you of course.
Quote:
The dosage in humans is no where near 200 mg/kg.
Thank you all. So informative . c ya at 100 a share. Eom
This is by far the BEST board on this pathetic website ...eom
Based in the xenograft models K (200 mg/kg) proved to be more effective than paclitaxel (22 mg/Kg)
With regards to paclitaxel dosing:
Activity for paclitaxel 135 mg/m2 and 200 mg/m2 by 1-hour infusion every 3 weeks in patients with NSCLC, with minimal myelosuppression and the suggestion of a dose-response relationship, has been reported. In November 1994, we initiated a phase II trial in patients with advanced, measurable, chemotherapy-naive NSCLC using paclitaxel 175 mg/m2 given in 1 hour, and carboplatin dosed to a fixed target area under the concentration-time curve of 7.5 every 3 weeks. In the absence of grade 4 myelosuppression, paclitaxel was escalated on an intrapatient basis by 35 mg/m2 per cycle to a maximum dose of 280 mg/m2 by cycle 4.
Kevetrin:
The dosing was been increased approximately 33 percent from the seventh cohort to 215 mg/m2.
At the end of day models are just guidelines to be taken with a grain of salt and maybe because of K very short 1/2 life and non-genotoxic properties this will allow it to dose patients more frequently, maybe the MTD is still far away . But I see your point with regards to efficacy vs current dosing escalation.
That is a sweet looking flag on the 3 year chart. Thanks for that visual. Breakout to the upside could be imminent and swift.
I'm done with you, seeker of truth. What a load of crap. Nothing like ignoring all evidence to the contrary.
Your post is not clear.
Please, repost in a more coherent form.
What exactly are you saying about how the results from the preclinical posters for animal studies performed a 200 mg/kg relate to the current 215 mg/sq m human phase I trial. Should we expect similar results?
What results do you expect from the current 215 mg/sq m dose in humans???
Good luck and GOD bless,
George
I don't know if there's anything untruthful in that post and I don't care.
Any value to the topics you introduced ended after your first two or three posts.
At this point, we really don't care anymore. Just... let... it... go.......
Yes, the assumption that human equivalency in tumor growth delay is simply dependent on a 200 mg/kg dose shown in mouse studies, and using that number as the benchmark for expectations. That is not truthful.
Quote:
Kevetrin may be a good combination with chemotherapy and/or radiation.
The dosage in humans is no where near 200 mg/kg.
Stop the bullshit challenges. I'm only pointing out that using body weight, or even BSA, for converting to HED for other than starting dose is much more complicated than using Baur's simple formula. The misapplication of that simplistic conversion has caused much confusion over the years. The article I referenced points to exactly that problem.
I challenge you, since you are a seeker of truth, to enter a Ph.D. program and seek the truth regarding formulations for HED. It's a wide open field of study.
Please note that I am ignoring your insult "Now that you seem to be willing to logically and intelligently pursue the truth..."
Can anyone find anything untruthful in this post???
Do not expect miracles from Kevetrin
Limit your expectations for the Kevetrin Phase I trial to the realistic goal of finding a safe MTD that shows promise when used in combination with chemotherapy and/ or radiation.
For example, Avastin was not approved until it showed promise when used in combination with chemotherapy for colorectal cancer. Avastin has since made $BILLIONS in sales and is used as a treatment in combination with chemotherapy and/or radiation for a wide variety of cancers. Expect similar results for Kevetrin.
http://www.fda.gov/newsevents/newsroom/pressa...108252.htm
Kevetrin may be a good combination with chemotherapy and/or radiation.
The dosage in humans is no where near 200 mg/kg.
http://cellceutix.com/wp-content/uploads/pdfs...-11x17.pdf
http://cellceutix.com/wp-content/uploads/pdfs...0FINAL.pdf
Good luck and GOD bless,
George
