Poseida Therapeutics Pursues New CAR-T Candidate with Roche Boost
Poseida Therapeutics Pursues New CAR-T Candidate with Roche Boost
Poseida Therapeutics, Inc. (NASDAQ: PSTX), a pioneer in advanced allogeneic cell therapies and genetic medicines, recently announced the nomination of a promising new CAR-T development candidate in its ongoing collaboration with Roche. This significant milestone not only highlights Poseida's commitment to innovation but also triggers a milestone payment of $15 million from Roche, enhancing Poseida's cash runway into early 2026.
Introducing a New Dual CAR-T Therapy
The newly nominated candidate is an allogeneic, dual CAR-T therapy, specifically designed to target antigens known to be expressed in hematologic malignancies, including multiple myeloma. Thanks to Poseida's expert capabilities in non-viral transposon-based DNA delivery, the company is able to insert genes for dual chimeric antigen receptors (CARs) into T stem cell memory cells (TSCM), which could lead to more effective treatment outcomes.
Statements from Leadership
Kristin Yarema, Ph.D., the President and CEO of Poseida Therapeutics, expressed excitement about the nomination, stating, "This new candidate underscores the potential of our proprietary genetic engineering toolkit to advance TSCM-rich CAR-T therapies. With the rise in multiple myeloma cases and a profound need for effective treatments, we are eager to move forward through our collaboration with Roche. We look forward to sharing progress on this program and other initiatives during our upcoming Cell Therapy R&D Day."
Collaboration with Roche and Key Programs
This recent nomination adds to the already fruitful partnership between Poseida and Roche, which initiated in August 2022, focusing on developing allogeneic CAR-T therapies targeting various hematologic malignancies. The lead program from this collaboration, P-BCMA-ALLO1, has received the Regenerative Medicine Advanced Therapy (RMAT) designation, demonstrating its potential for adult patients who have relapsed or are refractory to multiple therapies. Poseida is currently enrolling patients in the Phase 1b trial for this therapy, with promising data reported.
Upcoming Events
Poseida is set to host its Cell Therapy R&D Day on November 14, 2024. This virtual event will showcase presentations from key management and expert scientists detailing advancements in Poseida's innovative CAR-T therapies and other projects aimed at both oncology and autoimmune disease treatments. The access to the event and live webcast will be provided through their official channels, promising an informative gathering for stakeholders and interested parties.
Financial Outlook
From a financial perspective, as of June 30, 2024, Poseida reported a robust cash position with $237.8 million in cash, cash equivalents, and short-term investments. The $15 million milestone payment from Roche, along with anticipated near-term payments under their collaboration agreement, is expected to support the company's operations and advancements through early 2026. Additional collaborations and business developments may further enhance their financial stability.
About Poseida Therapeutics, Inc.
Poseida Therapeutics stands as a clinical-stage biopharmaceutical company dedicated to developing cutting-edge allogeneic cell therapies and genetic medicines aimed at addressing significant unmet medical needs. Their pipeline highlights investigational therapies tailored for conditions spanning hematologic cancers to autoimmune diseases. With a strong foundation in proprietary genetic editing technologies, Poseida partners strategically with leaders like Roche to maximize the potential of their therapies to benefit cancer patients.
Frequently Asked Questions
What is the significance of the new CAR-T candidate for Poseida Therapeutics?
The new CAR-T candidate represents a major milestone, allowing Poseida to advance its innovative therapies for hematologic malignancies, enhancing its treatment portfolio.
How does the collaboration with Roche benefit Poseida's developments?
The collaboration provides Poseida with substantial financial support and allows access to Roche's expertise in drug development, increasing the chances of successful clinical outcomes.
When is the Poseida Cell Therapy R&D Day planned?
The Cell Therapy R&D Day is scheduled for November 14, 2024, where Poseida will present updates on its pipelines and research findings.
What are Poseida's main areas of focus in its therapy development?
Poseida focuses on allogeneic CAR-T therapies targeting hematologic cancers, autoimmune diseases, and solid tumors, underpinned by its proprietary genetic editing platforms.
What is the expected financial trajectory for Poseida Therapeutics?
With its current cash position and anticipated milestone payments, Poseida aims to sustain operations into 2026, focusing on advancing its clinical programs successfully.
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