Polyrizon's Innovative Nasal Hydrogel Technology Unveiled

Polyrizon Shows Promise with Breakthrough Nasal Hydrogel Technology

Polyrizon Ltd. (Nasdaq: PLRZ) has portrayed robust advancements in their innovative intranasal hydrogel technologies. Their recent preclinical studies indicate an impressive mucoadhesive strength alongside extensive surface coverage of their proprietary formulation. This development is pivotal for both localized therapeutic interventions and as a protective barrier in the nasal cavity.

Understanding Recent Ex Vivo Studies

Collaboration with Prof. Fabio Sonvico's laboratory led to the utilization of excised rabbit nasal mucosa to simulate human nasal tissues. These studies aimed to evaluate critical attributes of Polyrizon's formulation, including its ability to cover nasal surfaces effectively and its mucoadhesive performance. The insights gained here are essential in combatting airborne biological threats.

Significant Findings on Surface Coverage

Through advanced ex vivo studies, including two-photon fluorescence microscopy, it has been evidenced that Polyrizon’s formulation quickly and uniformly adheres to the nasal mucosa. This rapid spread ensures the formation of a consistent surface layer crucial for delivering therapeutic compounds directly where they are most needed.

Enhanced Mucoadhesion for Extended Efficacy

Furthermore, testing revealed that this formulation maintains a compelling adherence even under conditions that simulate physiological fluid flows typical of a nasal environment. Such retention is vital for ensuring that the therapeutic effects are sustained over time, addressing the challenges posed by mucociliary clearance.

Insights from Company Leadership

Tomer Izraeli, CEO of Polyrizon, expressed optimism regarding these findings, highlighting their formulation's capability to provide localized protection and effective delivery. He emphasized that the mucoadhesive profile is crucial in clinical scenarios, as maintaining therapeutic action amid real-world nasal conditions can significantly enhance treatment outcomes.

Overview of Polyrizon’s Technology

Polyrizon specializes in crafting cutting-edge medical device hydrogels in the form of nasal sprays. These hydrogels outperform traditional methods by creating a thin protective barrier in the nasal cavity that acts as a shield against viruses and allergens. Their proprietary Capture and Contain (TM) hydrogel leverages naturally derived materials, offering a biological mask that could redefine nasal protection in medical applications.

Looking Ahead with Drug Delivery Innovations

In addition to its mucoadhesive hydrogels, Polyrizon is advancing its Trap and Target (T&T) technology, aimed at the nasal delivery of active pharmaceutical ingredients (APIs). The ongoing preclinical developments present exciting opportunities to enhance how medications are delivered intranasally.

Commitment to Safety and Efficacy

Polyrizon's focus extends beyond just providing immediate protective measures. They are committed to ensuring that their formulations are not only effective but also safe for diverse applications. This dedication reflects their mission to create reliable solutions for healthcare challenges.

Frequently Asked Questions

What is Polyrizon’s primary focus?

Polyrizon focuses on the development of innovative intranasal hydrogels designed to protect against biological threats and enhance drug delivery.

How does Polyrizon's hydrogel work?

The hydrogel forms a thin coating in the nasal cavity that acts as a shield against viruses and allergens while potentially delivering therapeutic compounds effectively.

What are the promising results from their recent studies?

Recent studies showed strong mucoadhesion and uniform surface coverage of the hydrogel on nasal mucosa, indicating its potential efficacy in real-world conditions.

What technologies is Polyrizon developing?

Polyrizon is advancing its Capture and Contain (C&C) technology and Trap and Target (T&T) technology, focusing on drug delivery and extended retention in the nasal cavity.

Who can I contact for more information about Polyrizon?

For investor relations inquiries, you can contact Michal Efraty at IR@polyrizon-biotech.com.

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