PolTREG Advances Treg Cell Therapy for Type-1 Diabetes Patients

Promising Results of PTG-007 in Type-1 Diabetes Treatment

PolTREG S.A. is leading the way in innovative therapies for autoimmune diseases. Their remarkable cellular therapy, PTG-007, has demonstrated impressive outcomes in patients suffering from Type-1 Diabetes (T1D). Recent data shows that some individuals have experienced clinical remission lasting up to twelve years, transforming their daily lives and significantly reducing their dependence on insulin.

Long-term Impact and Clinical Remission

Among the patients studied, a notable proportion achieved insulin independence for periods ranging from 18 to 24 months. This data was recently revealed at the INNODIA EASD conference, demonstrating the effectiveness of PTG-007 in managing an often relentless condition like T1D.

Understanding Treg Therapy

While treating T1D is complex, Tregs, or regulatory T cells, are crucial in maintaining immune system balance. In this study, PolTREG monitored 54 patients who participated in the initial phases of clinical trials. They found that a subset of these patients retained their clinical remission status from 7 to 12 years after undergoing treatment.

Combination Treatments Enhance Results

When combining PTG-007 with the standard anti-CD20 treatment, rituximab, patients displayed better outcomes concerning their insulin levels after meals. The study examined over 700 health metrics, such as heart function, microcirculation, and kidney performance, confirming that treatment with Tregs presented no downside compared to conventional care.

Commitment to Safety and Efficacy

Importantly, the therapy showed no severe adverse effects, underscoring PolTREG’s dedication to patient safety. As these findings pave the way for a pivotal Phase 2/3 study of PTG-007, the company is eager to partner with leading organizations to further advance this promising treatment into broader clinical use.

Expanding Opportunities for Treg Therapies

PolTREG continues to expand its robust pipeline of Treg therapies, focusing on polyclonal and engineered solutions. Their lead candidate, PTG-007, is currently in advanced clinical studies targeting T1D and multiple sclerosis (MS). Later in the year, they plan to begin Phase 2 trials for presymptomatic T1D patients.

Future Aspirations

Next year, the company anticipates starting first-in-human trials for its engineered CAR-Tregs designed to treat MS and amyotrophic lateral sclerosis (ALS). With a preclinical focus on additional engineered Treg types, PolTREG is strategically positioned at the forefront of innovative autoimmune therapies.

State-of-the-Art Manufacturing Facilities

Essential to its operation, PolTREG maintains a GMP-certified manufacturing facility, one of the largest and most advanced in Europe. This facility supports the production of next-generation therapies, with capabilities to ship cellular products across Europe within a single day, ensuring rapid access for patients in need.

About PolTREG

As a trailblazer in Treg therapy for autoimmune disorders, PolTREG is on a mission to revolutionize treatment approaches for diseases like Type-1 Diabetes. Their positive results and ongoing commitments signal promising advancements in patient care and treatment modalities.

Frequently Asked Questions

What is PTG-007?

PTG-007 is a Treg cell therapy developed by PolTREG to treat Type-1 Diabetes, showing potential for long-term clinical remission.

What were the results of the recent clinical study?

The study indicated that some patients achieved remission for up to 12 years and insulin independence for 18 to 24 months post-treatment.

What is the next step for PolTREG?

PolTREG aims to enter a pivotal Phase 2/3 study for PTG-007 and is currently seeking partnership funding.

Are there any side effects associated with PTG-007?

The therapy showed no severe adverse effects in the clinical studies, demonstrating a strong safety profile.

How does PolTREG's manufacturing process support its therapies?

PolTREG operates a large GMP-certified facility, which enhances its ability to produce high-quality Treg therapies efficiently.

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