Plus Therapeutics' Innovative Approach in Treating Recurrent Glioblastoma

Plus Therapeutics' Innovative Research at the CNS Annual Meeting

AUSTIN, Texas — Plus Therapeutics, Inc. (NASDAQ: PSTV), a pioneering clinical-stage pharmaceutical company, is gearing up to present significant findings from its ReSPECT-GBM Phase 2 trial at the upcoming Congress of Neurological Surgeons Annual Meeting. This annual event, attended by leading professionals in neurology and neurosurgery, will be held from September 28 to October 2 in Houston, Texas.

Significant Trial Presentation Details

The presentation will focus on the treatment of recurrent glioblastoma (rGBM), a devastating form of brain cancer that affects thousands of patients each year. The highlight will be the update on the innovative use of Rhenium-186 Obisbemeda, a specially designed therapeutic radiopharmaceutical that encompasses advanced delivery methods to address this critical health issue.

The Focus of the Presentation

Dr. John Floyd, a renowned Associate Professor and Chairman of Neurosurgery at UT Health Science San Antonio, will be delivering the presentation titled, “Treatment of Recurrent Glioblastoma via Convection Enhanced Delivery with Rhenium-186 Obisbemeda: ReSPECT-GBM Phase 2 Trial Update.” This session is scheduled for Monday, September 30, 2024, from 7:00 to 8:30 a.m. CDT, held in Room 310C of the George R. Brown Convention Center.

Understanding Recurrent Glioblastoma

Recurrent GBM is known to be one of the most aggressive and lethal forms of brain cancer, with approximately 15,000 new cases diagnosed annually in the United States alone. The prognosis for those diagnosed is grim; the average life expectancy is less than two years, with a shockingly low five-year survival rate of just around 5%. The current treatment landscape for recurrent GBM lacks effective options, leading to a dire need for new therapeutic approaches.

Statistical Insights

The complexity of GBM is compounded by its high propensity for recurrence, with about 90% of patients experiencing tumor return in or near the initial location. Unfortunately, existing FDA-approved therapies fall short in providing substantial survival benefits, forcing healthcare professionals and patients alike to seek innovative solutions.

Introducing Rhenium-186 Obisbemeda

Rhenium-186 Obisbemeda represents a breakthrough in targeted radiotherapy, designed to optimize the delivery of radiation directly to CNS tumors. This novel injectable therapy leverages the short half-life of Rhenium-186, providing a potent method for delivering localized and effective treatment while minimizing exposure to surrounding healthy tissues.

How It Works

This innovative treatment utilizes Convection Enhanced Delivery (CED), a minimally invasive technique that allows for the direct infusion of therapeutic agents into brain tumors through specialized catheters. This targeted delivery system aims to enhance therapeutic efficacy and improve patient outcomes by confining the action of the treatment to the tumor site.

Future Perspectives for Plus Therapeutics

Plus Therapeutics is committed to transforming treatment paradigms for challenging cancers of the central nervous system. Their research is bolstered by collaborations with the National Cancer Institute and the Cancer Prevention & Research Institute of Texas, showcasing their dedication to pioneering advancements in oncology.

Corporate Overview

Plus Therapeutics' mission revolves around the development of targeted radiotherapeutics that improve cancer treatment outcomes through innovative methodologies. The company is focused on enhancing its pipeline of drug candidates and is poised to make meaningful contributions to the fields of neurology and oncology.

Frequently Asked Questions

What is the main focus of Plus Therapeutics at the CNS Annual Meeting?

Plus Therapeutics will present significant data on their ReSPECT-GBM Phase 2 trial, concentrating on new treatment methodologies for recurrent glioblastoma.

Who is presenting the findings from the ReSPECT-GBM trial?

Dr. John Floyd, an esteemed Associate Professor and Chairman of Neurosurgery, will be the main presenter for the session.

What is Rhenium-186 Obisbemeda?

Rhenium-186 Obisbemeda is a novel injectable radiotherapy aimed at delivering targeted radiation treatment directly to CNS tumors to enhance patient outcomes.

Why is recurrent glioblastoma considered a challenging condition?

Recurrent glioblastoma is extremely aggressive, with poor prognosis and survival rates. Currently approved treatments yield limited benefits with substantial side effects.

How does Convection Enhanced Delivery work?

The CED method involves the surgical placement of small catheters into brain tumors, allowing for direct and targeted infusion of therapeutic agents, improving efficacy and reducing collateral damage to healthy tissues.

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