Plexium Showcases Groundbreaking Research at AACR 2025
Plexium Showcases Groundbreaking Research at AACR 2025
Plexium, Inc., a frontrunner in the field of targeted protein degradation, has recently announced remarkable developments that will be presented at the upcoming American Association for Cancer Research (AACR) Annual Meeting. This prestigious conference will spotlight the company's initial Phase 1 clinical results involving PLX-4545, a selective IKZF2 molecular glue degrader. In addition, exciting preclinical findings from their innovative SMARCA2 monovalent direct degrader and CDK2 molecular glue degrader programs will also be highlighted.
The annual AACR meeting, a key event in oncology, serves as a platform for researchers and practitioners to share cutting-edge advancements and insights. Plexium is eager to showcase their significant contributions to the science of cancer treatment, amplifying the relevance of their research within this prominent gathering of experts.
Oral Presentations to Highlight Key Findings
The event will feature two oral presentations focused on breakthroughs in the field:
Discovery of Novel CDK2 Molecular Glue Degrader
One presentation will delve into the intriguing topic of a novel CDK2 molecular glue degrader designed to tackle CCNE1-amplified tumors. The abstract number for this presentation is 6375, and it will take place on April 29 at 2:55 PM.
Reprogramming Tregs with PLX-4545
The second presentation will discuss how PLX-4545, as a selective IKZF2 degrader, reprograms suppressive Tregs, leading to tumor growth inhibition and enhanced outcomes when combined with immune checkpoint therapy. This session is set for April 29 at 4:10 PM, with abstract number 6380.
Poster Presentation Highlights
Alongside the oral presentations, Plexium will feature several poster presentations, shedding light on their rigorous research efforts:
Mechanistic Characterization of SMARCA2
A poster will examine the mechanistic characterization of selective monovalent direct degraders of SMARCA2, set for April 27 from 2:00 PM to 5:00 PM.
Preclinical Insights into PLX-61639
Another poster will explore the preclinical characterization of PLX-61639, a potent SMARCA2-selective monovalent direct degrader, scheduled for April 28 from 9:00 AM to 12:00 PM.
Importance of Connections in Oncology
Such presentations not only demonstrate Plexium's innovative research but also emphasize the importance of collaboration and networking within the oncology community. The shared knowledge contributes to a greater understanding of protein degradation strategies that could revolutionize treatments for cancer.
Plexium's Chief Medical Officer, Jorge F. DiMartino, expressed his excitement regarding the upcoming presentations, affirming that showcasing their research at AACR underscores the company's commitment to advancing the science of targeted protein degradation.
About Plexium, Inc.
Plexium stands out as a next-generation Targeted Protein Degradation (TPD) company driven to overcome the limitations faced by earlier generations of degraders. Their unique approach combines proprietary technologies with advanced AI-integrated drug discovery capabilities. This cutting-edge platform allows Plexium to identify small molecules that facilitate the selective degradation of target proteins, making significant strides in cancer treatment and addressing other critical health concerns.
Contact Information
For more inquiries or information about Plexium, key contacts include:
Amy Conrad
Juniper Point
Email: [email protected]
Phone: 858-366-3243
Frequently Asked Questions
What is Plexium's main focus in research?
Plexium primarily focuses on advancing next-generation targeted protein degradation therapies for cancer treatment.
When will Plexium present at the AACR Annual Meeting?
Plexium will present from April 25 to April 30, highlighting key findings from their innovative research.
What are some of the main presentations at AACR 2025?
Key presentations include findings on CDK2 molecular glue degraders and the effects of PLX-4545 on Tregs.
How does Plexium's research contribute to cancer treatment?
Plexium's research aims to provide effective degradation strategies that can lead to improved cancer therapies with greater efficacy and fewer side effects.
Who are the main contributors to Plexium's research efforts?
The team at Plexium, led by experts such as Chief Medical Officer Jorge F. DiMartino, advances the company's commitment to innovative protein degradation solutions.
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