Pharvaris Expands Deucrictibant Program Amid Positive Developments
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Pharvaris Announces Key Developments in Deucrictibant Program
Pharvaris, a biopharmaceutical company focused on therapies for hereditary angioedema (HAE), is making significant strides in its development program for deucrictibant, a novel bradykinin B2 receptor antagonist. One of the most exciting announcements is the planned initiation of CHAPTER-3, a pivotal Phase 3 clinical study aimed at evaluating the efficacy and safety of deucrictibant in patients suffering from HAE. This global study is anticipated to begin by the end of 2024.
Details of the CHAPTER-3 Study
CHAPTER-3 will focus on the prophylactic treatment of HAE utilizing an extended-release formulation of deucrictibant. This approach is designed to offer patients sustained protection from HAE attacks by maintaining therapeutic plasma levels for over 24 hours. According to Pharvaris, this study aims to confirm the benefits of once-daily dosing and its potential to improve the quality of life for individuals living with HAE.
Projected Impact and Future Directions
Pharvaris is also keen to explore the potential of deucrictibant in treating acquired angioedema (AAE-C1INH). This reflects the company's commitment to addressing various forms of bradykinin-mediated diseases. Such developments highlight Pharvaris's ambition to provide comprehensive care for angioedema patients and expand the therapeutic landscape significantly.
Positive Reception from the Medical Community
Berndt Modig, CEO of Pharvaris, expressed optimism about the future of deucrictibant, citing recent data that emphasizes its efficacy and tolerability in both prophylactic and on-demand treatment settings. The forthcoming presentations at the 2024 Bradykinin Symposium will further showcase the unique profile of deucrictibant, aiming to solidify its status as a preferred therapy for managing HAE.
Clinical Evidence Supporting Deucrictibant
The burgeoning body of data supporting deucrictibant's use continues to gain attention. Recent findings from investigator-initiated trials indicate that deucrictibant has successfully reduced the frequency of HAE attacks while demonstrating a favorable safety profile. As ongoing studies continue to yield positive results, Pharvaris aims to solidify deucrictibant’s place in the HAE treatment paradigm.
Engagement with Stakeholders
As part of its dedication to transparency and communication, Pharvaris plans to hold a conference call to discuss its latest updates in detail. During this session, stakeholders will have the opportunity to learn more about the company's plans and ask questions about its ongoing studies and future direction.
About Pharvaris and Deucrictibant
Pharvaris specializes in developing oral bradykinin B2 receptor antagonists, with deucrictibant at the forefront. Through this innovative approach, Pharvaris aims to provide effective, well-tolerated alternatives for managing angioedema, targeting not only HAE but also AAE due to C1-inhibitor deficiency. With plans for clinical expansions and robust supportive data, Pharvaris is positioning itself as a leader in the management of bradykinin-mediated angioedema.
Frequently Asked Questions
What is deucrictibant?
Deucrictibant is an oral bradykinin B2 receptor antagonist being developed by Pharvaris for the treatment of hereditary angioedema (HAE) and acquired angioedema (AAE).
What is the CHAPTER-3 study?
CHAPTER-3 is a pivotal Phase 3 clinical study set to assess the efficacy and safety of deucrictibant for the prophylactic treatment of HAE, commencing by the end of 2024.
How does deucrictibant work?
Deucrictibant functions by inhibiting bradykinin signaling, thereby preventing the occurrence of HAE attacks and managing symptoms if they arise.
What are the key goals of Pharvaris regarding deucrictibant?
Pharvaris aims to establish deucrictibant as a preferred therapy for HAE treatment and to explore its use in treating acquired angioedema, enhancing options for patients.
When will Pharvaris provide further updates on deucrictibant?
Pharvaris is expected to provide updates during their upcoming conference call and presentations at the Bradykinin Symposium and other medical conferences.
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