Palisade Bio Unveils Insights on PDE4B for Patient Stratification
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Palisade Bio Unveils Insights on PDE4B for Patient Stratification
Recent studies highlight the expression of PDE4B in patient cohorts, suggesting its potential to serve as a valuable marker for stratifying patients suffering from ulcerative colitis (UC). In a notable find, approximately 70% of adult colitis patients and 90% of pediatric patients exhibited PDE4B levels surpassing a defined threshold.
Advancements with PALI-2108
Palisade Bio is steadfast in developing PALI-2108, an innovative orally administered prodrug designed specifically for the colon. This localized PDE4 inhibitor is being evaluated for its efficacy against UC. The company is on track to initiate a Phase 1 clinical trial for PALI-2108, further underline its commitment to advancing treatment options for patients facing this chronic condition.
The Collaboration with Strand Life Sciences
As part of its strategic partnership with Strand Life Sciences, Palisade Bio has refined patient selection methods based on PDE4-related biomarkers. This development aims to enhance therapy outcomes for UC patients. RNA sequencing (RNAseq) data analyzed through a robust bioinformatics framework revealed a significant elevation of PDE4B expression across both adult and pediatric cohorts, reinforcing its potential role in distinguishing patient needs.
Understanding the Implications of PDE4B Expression
The analysis indicated that patients with moderate to severe UC often have heightened PDE4B expression, with 70% of adult patients and 90% of children meeting the criteria. Dr. Mitch Jones, Chief Medical Officer at Palisade Bio, remarked on the significance of these results, stating that PDE4B could be integral in guiding tailored treatment approaches, fostering increased personalization in care delivery.
Exciting Preclinical Findings
In a compelling preclinical study using a mouse model for DSS-induced colitis, notable increases in PDE4B levels occurred with DSS treatment. Researchers observed a direct correlation between elevated PDE4B and inflammation, which was mitigated with the administration of PALI-2108. The results demonstrated a decrease in disease activity index scores and improved outcomes in body weight and colon length metrics in treated groups, showcasing the drug's potential efficacy.
About Palisade Bio
Palisade Bio is a dedicated biopharmaceutical company focused on discovering and advancing novel therapies that address autoimmune, inflammatory, and fibrotic diseases. With a target-driven approach, Palisade aims to transform treatment paradigms for affected patients, strengthening its position in the industry.
Frequently Asked Questions
What is PDE4B and why is it important?
PDE4B is an enzyme that plays a critical role in regulating inflammation. Its expression levels can help identify patients who may benefit from targeted treatments for conditions like ulcerative colitis.
What is PALI-2108?
PALI-2108 is an orally administered prodrug that inhibits PDE4, specifically designed to act in the colon, aimed at treating ulcerative colitis.
How effective is PALI-2108 based on current studies?
Preliminary studies indicate that PALI-2108 demonstrates promising potential in reducing inflammation and improving clinical outcomes in preclinical models.
Who can benefit from the findings of this research?
The research findings may benefit patients suffering from moderate to severe ulcerative colitis by offering a more personalized treatment approach based on PDE4B expression levels.
Where can I find more information about Palisade Bio?
Additional information about Palisade Bio and its ongoing clinical programs can be found on their official website.
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