Oryzon Genomics Advances Patent for Vafidemstat in Psychiatric Treatment
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Oryzon's Patent Application Progress
Oryzon Genomics, S.A. is making significant strides in the biopharmaceutical sector by focusing on personalized medicines for central nervous system (CNS) disorders and oncology. Recently, the company celebrated a notable milestone with the European Patent Office (EPO), which issued an 'intention to grant' communication for their European patent application EP20712565.9. This patent centers around methodologies for treating borderline personality disorder (BPD) using vafidemstat, which is Oryzon's LSD1 inhibitor.
The Importance of This Patent Grant
Receiving an 'intention to grant' is a critical step for Oryzon, as it suggests the patent is almost certain to be approved. It highlights the innovative approaches Oryzon is taking in the treatment of psychiatric disorders, particularly BPD and schizophrenia. The granted patent will be valid until at least 2040, offering Oryzon a robust competitive edge in the market and assurance of its intellectual property rights.
Broader Patent Strategy
In addition to the EPO patent, Oryzon has also obtained similar communications for patent applications in other global markets, including Japan and Mexico. This expansion of their patent portfolio aims to fortify their position in the realms of neuroscience and psychiatry, serving the rising demand for effective treatment options for these severe disorders.
Oryzon's Commitment to CNS Disorders
The Chief IP Officer of Oryzon, Neus Virgili, expressed excitement regarding the patent, stating that it enhances their portfolio for vafidemstat in Central Nervous System applications. This strengthens their standing in the market, particularly following another patent grant that covers vafidemstat's use for aggression and social withdrawal in patients. The strategic importance of this patent cannot be understated as it can significantly prolong vafidemstat's commercial life within Europe.
Overview of Oryzon Genomics
Founded in 2000 in Spain, Oryzon has positioned itself as a leader in epigenetic research. The company is committed to advancing therapies through its innovative research team strategically located in Barcelona, Boston, and San Diego. Oryzon boasts an advanced clinical portfolio featuring LSD1 inhibitors such as vafidemstat, currently undergoing Phase II clinical trials in diverse conditions, reflecting their commitment to addressing significant unmet medical needs in CNS disorders and oncology.
Vafidemstat's Potential
Vafidemstat (ORY-2001) is a CNS-optimized oral LSD1 inhibitor that operates on multiple fronts, particularly in reducing cognitive impairment and neuroinflammation. Preclinical studies have shown promising results, including the ability to restore memory and reduce aggression in animal models. The efficacy of vafidemstat has been explored in various clinical trials targeting issues ranging from aggression to major psychiatric disorders like Alzheimer's.
Clinical Trials and Investigative Insights
Oryzon's commitment to clinical research is evident through completed clinical trials, including the REIMAGINE study, which focused on aggressive behaviors in patients suffering from various psychiatric conditions, and REIMAGINE-AD which targeted Alzheimer’s patients. The promising clinical results further emphasize vafidemstat's potential as a treatment for BPD, with plans for an End-of-Phase II meeting with the FDA to discuss a registrational Phase III trial based on results from the PORTICO study.
Looking Ahead
As Oryzon navigates through comprehensive research on vafidemstat and pursues many avenues in CNS personalized medicine, they are also eyeing the development of a clinical trial in patients with Kabuki Syndrome as well as other neurodevelopmental syndromes. With the FDA meeting on the horizon and ongoing trials, Oryzon aims to extend its reach within the therapeutic landscape, helping those who face the challenges of psychiatric disorders.
Frequently Asked Questions
What is the significance of the 'intention to grant' communication from the EPO?
This communication indicates that Oryzon's patent application for vafidemstat is on track to be approved, providing long-term protection in Europe.
What disorders is vafidemstat being tested for?
Vafidemstat is under investigation for its efficacy in treating borderline personality disorder, schizophrenia, aggression, and neurodegenerative diseases like Alzheimer's and multiple sclerosis.
When is the patent expected to be granted?
Once granted, the patent for vafidemstat will remain effective until at least 2040, securing Oryzon's intellectual property rights in the market.
What are the future plans for Oryzon?
Oryzon plans to conduct a registrational Phase III trial for BPD and is exploring additional applications of vafidemstat in various neurodevelopmental syndromes.
How can I learn more about Oryzon Genomics?
For more information about Oryzon Genomics and their research initiatives, you can visit their official website.
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