Orexo to Showcase OX640 Breakthrough at EAACI Congress 2025

Orexo to Showcase OX640 Breakthrough at EAACI Congress 2025

Orexo AB is set to make a significant mark at the upcoming EAACI Congress, where they will present clinical data concerning OX640, a promising nasal rescue medication. This medication leverages powder-based epinephrine to address severe allergic reactions, including anaphylaxis. OX640 is an innovative product that uses Orexo's proprietary AmorphOX® technology, which enhances drug delivery and absorption times.

About the EAACI Congress

EAACI, which stands for the European Academy of Allergy and Clinical Immunology, is recognized globally for its commitment to advancing understanding and treatment of allergies and immunological disorders. The congress attracts experts and practitioners from around the world, making it a vital event for the exchange of new ideas and research findings in the field of allergy treatment.

Presentation Details and Key Findings

During the congress, Dr. Anne K. Ellis, a leading figure in allergy and immunology from Queen's University, will present pivotal data from the OX640-002 clinical study. This research highlights a significant finding: under conditions of allergic rhinitis, epinephrine was absorbed much more quickly than under normal circumstances. This rapid absorption may provide critical benefits for patients facing acute allergic reactions, ensuring swift medical intervention.

Poster Presentation and Insights

In addition to the oral presentation, Robert Rönn, Orexo's Senior Vice President and Head of Research and Development, will showcase a scientific poster. This presentation will include detailed stability data for OX640, further emphasizing its effectiveness as a rescue option. Rönn is optimistic about the capabilities of OX640 and believes in its potential to offer patients a reliable and convenient solution.

About Orexo and Its Innovations

Founded in Sweden, Orexo has an impressive track record of over three decades in developing advanced pharmaceutical solutions. Throughout its history, the company has focused on addressing significant medical needs through innovative drug formulations. Currently, Orexo is especially renowned in the U.S. market for offering solutions that assist patients dealing with opioid use disorder. Furthermore, they are expanding their reach in treating other medical conditions globally by collaborating with esteemed partners.

OX640: Leading the Charge Against Allergic Reactions

OX640 stands out as a game-changer for those with severe allergies. Its formulation allows for rapid and effective systemic absorption, aiming to deliver fast relief without requiring injections. Unlike traditional methods, the ease of use of a nasal spray can transform the manner in which allergic patients manage emergencies. Patients can carry OX640 with them for quick access, potentially making a life-saving difference during critical moments.

The OX640-002 Clinical Study Overview

The OX640-002 study involved a comprehensive examination with 30 healthy participants exhibiting seasonal allergic rhinitis. This four-period cross-over study evaluated epinephrine absorption levels, heart rate, and blood pressure after administering both OX640 and intramuscular epinephrine. Findings showed that when OX640 was administered after allergen exposure, it replicated severe allergic response conditions, mirroring real-world scenarios faced by patients.

Future Directions and Company Vision

As Orexo prepares for this congress, it is motivated by its vision to continually innovate and expand the therapeutic options available for patients. The combination of AmorphOX technology with the practicality of OX640 aligns with Orexo's commitment to delivering high-quality solutions that address urgent health needs. Orexo remains steadfast in its ambition to collaborate and innovate, evolving alongside scientific advancements and the evolving landscape of healthcare.

Frequently Asked Questions

What is OX640?

OX640 is a nasal powder medication designed for the rapid treatment of severe allergic reactions, utilizing epinephrine for effective relief.

Who will present at the EAACI Congress?

Dr. Anne K. Ellis from Queen's University will lead the presentation, sharing essential data from the OX640-002 study.

What are the key findings of the OX640-002 study?

The study demonstrated that OX640 allows for faster absorption of epinephrine in conditions of allergic rhinitis, indicating a quicker onset of action.

How does OX640 differ from traditional allergy treatments?

OX640 offers a needle-free delivery option, providing convenience and flexibility in managing severe allergies, making it easier for patients.

What is Orexo's mission?

Orexo aims to develop innovative treatments that address major medical needs, focusing on allergic reactions and opioid use disorders among other areas.

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