Olema Oncology to Share Breakthrough Cancer Insights at 2024 Event

Olema Oncology's Innovative Presentations at Upcoming Symposium

Olema Pharmaceuticals, Inc. is gearing up for a notable presence at the highlighted EORTC-NCI-AACR Symposium, which focuses on molecular targets and cancer therapeutics. This prestigious event will take place in a vibrant European city, presenting an ideal platform for showcasing groundbreaking research that aims to revolutionize cancer treatment for women. As a clinical-stage biopharmaceutical company, Olema's commitment to women's health aligns perfectly with the symposium's theme.

Focused Research Presentation Details

During the symposium, Olema Oncology will present multiple posters detailing their innovative research in breast cancer treatments. Key highlights include:

Combination Therapies for Enhanced Tumor Suppression

One prominent presentation emphasizes the collaborative efforts of combining palazestrant, a complete estrogen receptor antagonist (CERAN), with everolimus, an mTOR inhibitor. This combination has demonstrated a significant boost in tumor suppression efforts in clinical models of ER+/HER2- breast cancer.

Exploring Further Synergies

Another session will focus on the exciting combination of palazestrant and capivasertib, a pan-AKT inhibitor. This innovative approach, too, aims to enhance anti-tumor efficacy specifically within ER+/HER2- breast cancer models, highlighting Olema's dedication to finding resilient and effective treatment pathways.

Important Session Information

The dedicated poster sessions will occur on October 24, 2024, from 09:00 to 17:30 CEST. Researchers and oncology experts attending this gathering can gain invaluable insights by visiting Poster Session 300 in the Exhibition Hall. Each abstract is crafted to spur robust discussions on future directions in cancer therapy.

Understanding Palazestrant (OP-1250)

Palazestrant represents a pivotal advancement in Olema's product pipeline. As a dual-acting molecule, it serves as both a CERAN and a selective estrogen receptor degrader (SERD). Designed for patients battling recurrent or metastatic ER-positive breast cancer, palazestrant has shown promising results, including complete inhibition of ER-driven transcriptional activity in various breast cancer scenarios.

Regulatory Milestones and Ongoing Trials

This pioneering compound has received the FDA’s Fast Track designation due to its potential in addressing advanced breast cancer that fails to respond to prior therapies. Olema is currently conducting a Phase 3 clinical trial, OPERA-01, to further its understanding and effectiveness in patient treatment, along with numerous combination studies to explore synergies with CDK4/6 inhibitors and other agents.

The Mission of Olema Oncology

Beyond treatment innovation, Olema Oncology stands as a beacon of hope for women navigating the complexities of cancer. With a keen focus on understanding endocrine-driven cancers, they are committed to not just improving outcomes but transforming the standard of care. Their pipeline underscores the innovative spirit infused within the organization, laying a foundation for potentially life-changing therapies.

Contact Information for More Insight

For those interested in learning more about Olema's endeavors or the upcoming presentations, Courtney O'Konek, the Vice President of Corporate Communications, can be reached via email. This engagement allows for deeper dives into both ongoing research and future aspirations.

Frequently Asked Questions

What is the focus of Olema Oncology's research?

Olema Oncology specializes in developing targeted therapies for women's cancers, particularly ER-positive breast cancer.

What will be presented at the EORTC-NCI-AACR Symposium?

Olema will present several posters highlighting combination therapies that enhance tumor suppression in breast cancer models.

What is palazestrant (OP-1250)?

Palazestrant is an innovative treatment that acts as both an estrogen receptor antagonist and a selective degrader, specifically targeting ER-positive breast cancers.

Why is palazestrant significant?

Palazestrant has received Fast Track designation from the FDA due to its potential effectiveness in hard-to-treat breast cancer cases.

How can one contact Olema Oncology for more information?

For inquiries, interested parties can reach out to Courtney O'Konek, Vice President of Corporate Communications, via email.

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