Nxera Pharma Advances Innovative OX2R Agonist, ORX750, Forward
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Positive Clinical Data for ORX750 in Sleep Disorders
In an exciting development for sleep disorder treatment, Centessa Pharmaceuticals recently shared interim Phase 1 clinical data, highlighting the progress made with its novel orexin receptor 2 (OX2R) agonist, ORX750. This investigational drug demonstrated statistically significant improvements in sleep latency for acutely sleep-deprived healthy individuals.
Impressive Results from Clinical Trials
During the trials, ORX750 produced clinically meaningful results, showcasing improvements in sleep latency, particularly with the two lowest doses tested (1.0 mg and 2.5 mg). Notably, the 2.5 mg dose facilitated a remarkable restoration of normative wakefulness, yielding an impressive mean sleep latency of 32 minutes during the Maintenance of Wakefulness Test (MWT).
Next Steps in Development
Following these successful results, Centessa plans to swiftly advance ORX750 into Phase 2 studies, targeting patients with narcolepsy types 1 and 2, as well as idiopathic hypersomnia. This phase is set to commence in the near future, with expectations to begin in the latter part of 2024.
Safety and Tolerability Analysis
One of the standout features of ORX750 is its favorable safety and tolerability profile. Clinical observations revealed no significant on-target adverse events commonly noted with other OX2R agonists, including hepatotoxicity or visual disturbances, across all tested dose levels.
About Nxera Pharma
Nxera Pharma, previously known as Sosei Heptares, is committed to developing innovative therapies tailored to meet the needs of patients with unmet medical conditions globally. With a robust pipeline exceeding 30 active programs, Nxera is dedicated to addressing challenges in various medical fields, including neurology and rare diseases.
Innovative Drug Discovery Approach
The company leverages its pioneering GPCR-targeted structure-based drug discovery platform, NxWave™, to identify promising candidates. More than 350 professionals at Nxera contribute to advancing research and development initiatives across locations in Japan, the UK, Switzerland, and South Korea.
Investment and Future Directions
The progress of ORX750 signifies the ongoing collaboration and commitment between Nxera Pharma and Centessa Pharmaceuticals. As the latter continues to advance ORX750 into more advanced clinical stages, Nxera will remain attentive to any pivotal milestone events that could lead to significant financial implications for both companies.
Frequently Asked Questions
What is ORX750 and its intended use?
ORX750 is an investigational drug targeting orexin receptor 2, aimed at treating sleep disorders, especially narcolepsy.
How did ORX750 perform in clinical trials?
The drug showed significant improvements in sleep latency, particularly at the 2.5 mg dose, indicating its potential effectiveness.
What are the next steps for ORX750?
Centessa plans to move ORX750 into Phase 2 studies focusing on narcolepsy and idiopathic hypersomnia in 2024.
What safety profile does ORX750 have?
ORX750 demonstrated a favorable safety profile with no common adverse events associated with other OX2R agonists during trials.
What is the background of Nxera Pharma?
Nxera Pharma is focused on developing new specialty medicines and has a strong pipeline aimed at various medical fields.
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