Nordic Bioscience Unveils Groundbreaking Endotrophin Assay

Introducing the Innovative Endotrophin Assay from Nordic Bioscience

Nordic Bioscience is excited to announce their latest product, nordicEndotrophin™, a fully automated high-precision assay designed to measure the intact 77-amino-acid Endotrophin signaling hormone. This groundbreaking assay has been qualified in their CAP/CLIA certified laboratory, ensuring reliable results. By integrating nordicEndotrophin™ with their established biomarker range, Nordic Bioscience aims to enhance the prognostic utility in fibrosis and cancer research.

A Comprehensive Solution for Chronic Disease Assessment

NordicEndotrophin™ complements the existing assays, nordicPRO-C6™ and nordicPRO-C3™, which serve as in-house versions of the FDA-supported PRO-C6 and CE-approved PRO-C3 tests respectively. This merger provides a streamlined solution for assessing the fibro-inflammatory axis amidst chronic conditions such as cardiovascular issues, obesity, and more. Following the successful incorporation of PRO-C3 on Roche IVD platforms, the addition of the Endotrophin assay bolsters risk stratification and pharmaceutical monitoring.

Understanding the Role of Endotrophin in Health

Discovered in 2012, Endotrophin is a collagen-derived hormone produced from type VI collagen, a vital contributor to fibroblast activation and fibrosis across various organs. Remarkably, about 40 percent of deaths in many Western nations are linked to underlying inflammatory processes driven by this collagen type. The situation is aggravated by obesity, which activates fibroblasts in critical organs like the liver, kidney, and heart. Notably, a doubling in circulating Endotrophin levels can increase the risk of mortality by 100%. Hence, the ability to quantify this biomarker opens doors for researchers to connect wound healing and fibrotic progression to patient outcomes, thus paving the way for precision medicine approaches.

A Closer Look at the Assay's Specificity

Unlike Nordic Bioscience's earlier PRO-C6 assay—which measures the total formation of type VI collagen—nordicEndotrophin™ focuses solely on the intact 77-amino-acid hormone. This distinguishing feature heightens the prognostic value and risk stratification capabilities, providing a comprehensive understanding of fibrotic conditions. CEO Dr. Morten Karsdal emphasizes the significance of that specificity, noting that in studies involving HFpEF patients, both Endotrophin and PRO-C6 showed superior performance compared to traditional markers like NT-proBNP.

Facilitating Drug Development and Clinical Trials

Offered at Nordic Bioscience's certified laboratory in Herlev, the nordicEndotrophin™ assay stands out for its high precision and automation, designed for high-throughput platforms. Customers exploring nordicEndotrophin™ are encouraged to pair it with nordicPRO-C3™ and nordicPRO-C6™ for optimal results. This strategy not only aids in risk stratification but also supports dose selection, patient enrichment, and monitoring during anti-fibrotic and oncology trials.

About Nordic Bioscience

Nordic Bioscience, based in Denmark, is at the forefront of biomarker innovation. Utilizing unique neoepitope technology, the company merges its expertise in developing biomarkers with preclinical and clinical research. This integration allows for an accelerated decision-making process in clinical trials and ensures that patients receive diagnostic value. With a commitment to enhancing healthcare, Nordic Bioscience is shaping the future of biomarker development.

Frequently Asked Questions

What is NordicEndotrophin™?

NordicEndotrophin™ is a high-precision, fully automated assay that quantifies the Endotrophin hormone, which is crucial in assessing fibrotic conditions.

How does the new assay fit into existing products?

It complements the nordicPRO-C6™ and nordicPRO-C3™ assays, creating a comprehensive solution for studying chronic diseases.

Why is Endotrophin important?

Endotrophin is linked to fibrosis-related health issues. Quantifying it helps in connecting wound healing to patient outcomes.

Where is the assay available?

The nordicEndotrophin™ assay is offered in Nordic Bioscience's certified laboratory in Herlev, Denmark.

What sets this assay apart from others?

This assay specifically measures the intact 77-amino-acid Endotrophin, allowing for enhanced risk stratification and prognostic insights.

About The Author

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