Neurocrine Biosciences Unveils CRENESSITY™ for CAH Patients

Neurocrine Biosciences Launches CRENESSITY™ for Managing CAH

Neurocrine Biosciences, Inc. (NASDAQ: NBIX) is thrilled to announce that CRENESSITY™ (crinecerfont), a groundbreaking therapy for classic congenital adrenal hyperplasia (CAH), is now available in the United States. This first-in-class treatment represents a significant advancement in medical care for individuals affected by this rare genetic disorder.

Understanding CRENESSITY's Role in Congenital Adrenal Hyperplasia

CRENESSITY is designed to be an adjunctive treatment that helps manage androgen levels in both children and adults aged four years and older suffering from classic CAH. This innovative therapy has been recognized for its ability to enable patients to maintain effective hormone levels while reducing their reliance on high-dose glucocorticoids, which can lead to various health complications.

Key Features of CRENESSITY

CRENESSITY is a selective oral corticotropin-releasing factor type 1 receptor (CRF₁) antagonist which works by lowering the production of adrenocorticotropic hormone and subsequently, adrenal androgens. This unique approach allows patients to achieve better management of their condition, resulting in lower doses of glucocorticoids while sustaining or improving androgen levels.

Support for Patients and Families

Neurocrine Biosciences understands the complexities families face in managing CAH. According to Kyle W. Gano, Ph.D., the company's CEO, the introduction of CRENESSITY is a pivotal moment for patients who have long endured challenges associated with high-dose steroid therapies. To further support this community, Neurocrine offers Neurocrine Access Support, providing comprehensive assistance and resources to help patients navigate treatment options.

Collaboration with Specialty Pharmacy for Seamless Access

To streamline access to this essential medication, CRENESSITY is provided exclusively through PANTHERx Rare, a specialty pharmacy where trained pharmacists are available around the clock. They are ready to assist with prescription inquiries and ensure that patients receive consistent support while using CRENESSITY.

Commitment to Affordable Care

Neurocrine’s commitment to ensuring affordable care is demonstrated by the anticipated out-of-pocket costs for patients. The company projects that 90% of individuals using CRENESSITY will pay monthly copays of $12 or less. This intention to provide accessible treatment is part of the broader mission of Neurocrine Biosciences.

Clinical Trials and FDA Approval

The FDA's approval of CRENESSITY was backed by the largest clinical trial program ever conducted for classic CAH, which included both pediatric and adult studies. The CAHtalyst studies evaluated the safety and efficacy of CRENESSITY among a diverse patient population, solidifying its role as a preferred treatment option.

Exploring Congenital Adrenal Hyperplasia

Congenital adrenal hyperplasia is characterized by a deficiency in adrenal steroid hormone production due to enzyme deficiencies, impacting cortisol and aldosterone levels. This can lead to severe complications if not treated effectively. Historically, patients had to rely on exogenous glucocorticoids, which could result in significant side effects, including metabolic issues and psychological impacts. The introduction of CRENESSITY aims to mitigate these concerns by offering a non-glucocorticoid treatment pathway.

Innovative Mechanism of Action

CRENESSITY works by antagonizing CRF₁ receptors in the pituitary, leading to a decrease in ACTH levels, which in turn reduces adrenal androgen production. This innovative mechanism not only addresses the hormonal imbalances resulting from CAH but also aims to improve the overall quality of life for patients.

FAQs about CRENESSITY and CAH

What is CRENESSITY used for?

CRENESSITY is used in conjunction with glucocorticoids to manage androgen levels in patients aged four and older with classic congenital adrenal hyperplasia.

How does CRENESSITY work?

This medication functions by blocking specific receptors that regulate hormone production, thereby reducing excess adrenal androgens.

Where can patients access CRENESSITY?

CRENESSITY is available through PANTHERx Rare, a specialty pharmacy dedicated to providing support and guidance to patients.

What should patients know about dosing?

Dosage recommendations for CRENESSITY depend on the patient's age and weight, with specific guidelines for children and adults outlined by healthcare providers.

Is there any financial assistance available for CRENESSITY?

Neurocrine Access Support offers resources to help patients navigate insurance and identify financial assistance options, ensuring that treatment is accessible.

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