NeoImmuneTech Unveils Breakthrough Results for CAR-T Therapy

Exciting Advances in CAR-T Therapy with NT-I7

NeoImmuneTech, Inc. has made remarkable progress in improving CAR-T cell therapies, an innovative treatment aimed at fighting cancers. Interim results from the Phase 1b clinical trial highlighting the combination of NT-I7 (efineptakin alfa) with CAR-T therapy have shed light on the potential this approach holds for enhancing patient care.

Challenges in CAR-T Cell Therapy

While CAR-T therapies represent a significant advancement in cancer treatment, they often struggle with adequate cell expansion and long-term persistence. These factors can limit their efficacy during treatments. With the objective of addressing these challenges, NeoImmuneTech’s recent clinical findings reveal that using NT-I7 following CAR-T cell administration is both safe and well tolerated.

Overview of Clinical Trial NIT-112

The NIT-112 clinical trial focuses on patients diagnosed with Large B-cell Lymphoma (LBCL) who have undergone CAR-T therapies, such as Kymriah, Yescarta, or Breyanzi. Following their CAR-T infusion, participants received NT-I7 treatment 21 days later. The aim is to evaluate not just safety and tolerability but also to explore the recommended Phase 2 dose (RP2D), and the potential of NT-I7 to increase CAR-T expansion and durability.

Stable Safety Profile Observed

Early results from doses 4 and 5 of NT-I7 (360 and 480 µg/kg) show promising outcomes. Importantly, there were no reported cases of Cytokine Release Syndrome (CRS) or Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS), serious side effects often associated with CAR-T therapies. The observed mild side effects were manageable and affected a majority of the participants to a lesser degree.

Amplification of CAR-T Cells

The administration of NT-I7 significantly boosted CAR-T cell numbers, demonstrated prolonged cell persistence, and increased the proportion of T cells exhibiting a stem-cell memory phenotype. This resulted in an overall response rate (ORR) of 81.1% among participants, contrasting starkly with the 52% ORR observed in earlier studies involving Kymriah.

Insights from the CEO

Dr. Luke Oh, President and CEO of NeoImmuneTech, expressed his enthusiasm about the preliminary results of the NIT-112 study. He highlighted the significance of NT-I7 in amplifying CAR-T cells and its potential positive impact on patient outcomes. NeoImmuneTech plans to explore technology transfer opportunities on NT-I7's combination with CAR-T therapies, indicating a future where these treatments may become even more effective.

Understanding NT-I7 (efineptakin alfa)

NT-I7 is a long-acting human IL-7, crucial for T cell development and sustaining immune responses against chronic antigens like cancer. Its favorable pharmacokinetics/dynamics and safety characteristics make it a prime candidate for combination therapies. Ongoing research is investigating NT-I7’s potential in various cancer types and its use as a vaccine adjuvant.

Get to Know NeoImmuneTech, Inc.

NeoImmuneTech, Inc. is dedicated to advancing T cell-focused immunotherapies and enhancing the fight against infectious diseases. The company prides itself on a strong leadership team with extensive experience in the field. As NeoImmuneTech continues to grow, it remains committed to collaborating with both industry and academic leaders to explore the therapeutic avenues offered by NT-I7.

Frequently Asked Questions

What is the NIT-112 clinical trial about?

The NIT-112 trial investigates the safety and effectiveness of NT-I7 in conjunction with CAR-T cell therapies for patients with Large B-cell Lymphoma.

What are the main results of the interim findings?

Interim results show a stable safety profile for NT-I7, with an ORR of 81.1%, highlighting its potential to improve patient outcomes.

Who is leading NeoImmuneTech?

Dr. Luke Oh serves as the President and CEO, guiding the company’s innovative approach to immunotherapy.

What other clinical applications is NT-I7 being studied for?

NT-I7 is being evaluated not only in hematological malignancies but also in solid tumors and as a vaccine adjuvant.

How does NT-I7 enhance CAR-T therapies?

NT-I7 improves CAR-T cell persistence and expansion, thereby potentially increasing the overall effectiveness of the treatment.

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